PDB 4tyd

PDB Information

PDB4TYD
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHepatitis C virus (isolate 1)
Primary Citation
Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.
Parsy, C., Alexandre, F.R., Brandt, G., Caillet, C., Cappelle, S., Chaves, D., Convard, T., Derock, M., Gloux, D., Griffon, Y., Lallos, L., Leroy, F., Liuzzi, M., Loi, A.G., Moulat, L., Musiu, C., Rahali, H., Roques, V., Seifer, M., Standring, D., Surleraux, D.
Bioorg.Med.Chem.Lett.
HeaderHydrolase
Released2014-07-08
Resolution2.840
CATH Insert Date14 Sep, 2014

PDB Images (37)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 15 Sep, 2014 Chopped
B 15 Sep, 2014 Chopped
C 15 Sep, 2014 Chopped
D 15 Sep, 2014 Chopped
E 15 Sep, 2014 Chopped
F 15 Sep, 2014 Chopped
G 15 Sep, 2014 Chopped
H 15 Sep, 2014 Chopped
J 15 Sep, 2014 Chopped
K 15 Sep, 2014 Chopped
L 15 Sep, 2014 Chopped
M 15 Sep, 2014 Chopped

CATH Domains (24)

Domain ID Date inserted into CATH Superfamily CATH Status
4tydA01 16 Sep, 2014 2.40.10.120 Assigned
4tydA02 16 Sep, 2014 2.40.10.10 Assigned
4tydB01 16 Sep, 2014 2.40.10.120 Assigned
4tydB02 16 Sep, 2014 2.40.10.10 Assigned
4tydC01 16 Sep, 2014 2.40.10.120 Assigned
4tydC02 16 Sep, 2014 2.40.10.10 Assigned
4tydD01 16 Sep, 2014 2.40.10.120 Assigned
4tydD02 16 Sep, 2014 2.40.10.10 Assigned
4tydE01 16 Sep, 2014 2.40.10.120 Assigned
4tydE02 16 Sep, 2014 2.40.10.10 Assigned
4tydF01 16 Sep, 2014 2.40.10.120 Assigned
4tydF02 16 Sep, 2014 2.40.10.10 Assigned
4tydG01 16 Sep, 2014 2.40.10.120 Assigned
4tydG02 16 Sep, 2014 2.40.10.10 Assigned
4tydH01 16 Sep, 2014 2.40.10.120 Assigned
4tydH02 16 Sep, 2014 2.40.10.10 Assigned
4tydJ01 16 Sep, 2014 2.40.10.120 Assigned
4tydJ02 16 Sep, 2014 2.40.10.10 Assigned
4tydK01 16 Sep, 2014 2.40.10.120 Assigned
4tydK02 16 Sep, 2014 2.40.10.10 Assigned
4tydL01 16 Sep, 2014 2.40.10.120 Assigned
4tydL02 16 Sep, 2014 2.40.10.10 Assigned
4tydM01 16 Sep, 2014 2.40.10.120 Assigned
4tydM02 16 Sep, 2014 2.40.10.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q0ZNA6 Q0ZNA6_9HEPC Hepacivirus C NS3 protease
Q0ZNA6 Q0ZNA6_9HEPC Hepacivirus C NS3 protease
Q0ZNA6 Q0ZNA6_9HEPC Hepacivirus C NS3 protease
Q0ZNA6 Q0ZNA6_9HEPC Hepacivirus C NS3 protease
Q0ZNA6 Q0ZNA6_9HEPC Hepacivirus C NS3 protease
Q0ZNA6 Q0ZNA6_9HEPC Hepacivirus C NS3 protease
Q0ZNA6 Q0ZNA6_9HEPC Hepacivirus C NS3 protease
Q0ZNA6 Q0ZNA6_9HEPC Hepacivirus C NS3 protease
Q0ZNA6 Q0ZNA6_9HEPC Hepacivirus C NS3 protease
Q0ZNA6 Q0ZNA6_9HEPC Hepacivirus C NS3 protease
Q0ZNA6 Q0ZNA6_9HEPC Hepacivirus C NS3 protease
Q0ZNA6 Q0ZNA6_9HEPC Hepacivirus C NS3 protease