PDB Information

PDB4NXO
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Deprez-Poulain, R., Hennuyer, N., Bosc, D., Liang, W.G., Enee, E., Marechal, X., Charton, J., Totobenazara, J., Berte, G., Jahklal, J., Verdelet, T., Dumont, J., Dassonneville, S., Woitrain, E., Gauriot, M., Paquet, C., Duplan, I., Hermant, P., Cantrelle, F.X., Sevin, E., Culot, M., Landry, V., Herledan, A., Piveteau, C., Lippens, G., Leroux, F., Tang, W.J., van Endert, P., Staels, B., Deprez, B.
Nat Commun
HeaderHydrolase/Hydrolase Inhibitor
Released2013-12-09
Resolution2.730
CATH Insert Date18 Oct, 2015

PDB Images (11)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 19 Oct, 2015 Chopped
B 19 Oct, 2015 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4nxoA01 01 Nov, 2015 3.30.830.10 Assigned
4nxoA02 01 Nov, 2015 3.30.830.10 Assigned
4nxoA03 01 Nov, 2015 3.30.830.10 Assigned
4nxoA04 01 Nov, 2015 3.30.830.10 Assigned
4nxoB01 31 Oct, 2015 3.30.830.10 Assigned
4nxoB02 31 Oct, 2015 3.30.830.10 Assigned
4nxoB03 31 Oct, 2015 3.30.830.10 Assigned
4nxoB04 31 Oct, 2015 3.30.830.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P14735 IDE_HUMAN Homo sapiens Insulin-degrading enzyme
P14735 IDE_HUMAN Homo sapiens Insulin-degrading enzyme