1 keywords

CATH Domain 4nxoA03

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.830 Cytochrome Bc1 Complex; Chain A, domain 1
Homologous Superfamily 3.30.830.10 Metalloenzyme, LuxS/M16 peptidase-like

Domain Context

CATH Clusters

Superfamily Metalloenzyme, LuxS/M16 peptidase-like
Functional Family Insulin-degrading enzyme

Enzyme Information

3.4.24.56
Insulysin.
based on mapping to UniProt P14735
Degradation of insulin, glucagon and other polypeptides. No action on proteins.
-!- Cytosolic enzyme, known from mammals and Drosophila melanogaster. -!- Inhibited by bacitracin, chelating agents EDTA and 1,10- phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. -!- Belongs to peptidase family M16. -!- Formerly EC 3.4.22.11, EC 3.4.99.10 and EC 3.4.99.45.

UniProtKB Entries (1)

P14735
IDE_HUMAN
Homo sapiens
Insulin-degrading enzyme

PDB Structure

PDB 4NXO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Deprez-Poulain, R., Hennuyer, N., Bosc, D., Liang, W.G., Enee, E., Marechal, X., Charton, J., Totobenazara, J., Berte, G., Jahklal, J., Verdelet, T., Dumont, J., Dassonneville, S., Woitrain, E., Gauriot, M., Paquet, C., Duplan, I., Hermant, P., Cantrelle, F.X., Sevin, E., Culot, M., Landry, V., Herledan, A., Piveteau, C., Lippens, G., Leroux, F., Tang, W.J., van Endert, P., Staels, B., Deprez, B.
Nat Commun