PDB Information

PDB4LVB
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Zheng, X., Bair, K.W., Bauer, P., Baumeister, T., Bowman, K.K., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Feng, Y., Han, B., Ho, Y.C., Kley, N., Li, H., Liang, X., Liederer, B.M., Lin, J., Ly, J., O'Brien, T., Oeh, J., Oh, A., Reynolds, D.J., Sampath, D., Sharma, G., Skelton, N., Smith, C.C., Tremayne, J., Wang, L., Wang, W., Wang, Z., Wu, H., Wu, J., Xiao, Y., Yang, G., Yuen, P.W., Zak, M., Dragovich, P.S.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2013-07-26
Resolution1.840
CATH Insert Date06 Oct, 2013

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 07 Oct, 2013 Chopped
B 07 Oct, 2013 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4lvbA01 10 Oct, 2013 Holding pen
4lvbA02 10 Oct, 2013 3.20.20.70 Assigned
4lvbB01 10 Oct, 2013 Holding pen
4lvbB02 10 Oct, 2013 3.20.20.70 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P43490 NAMPT_HUMAN Homo sapiens Nicotinamide phosphoribosyltransferase
P43490 NAMPT_HUMAN Homo sapiens Nicotinamide phosphoribosyltransferase