PDB 4ktc

PDB Links
Overview

PDB Information

PDB	4KTC
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Hepatitis C virus (isolate Japanese)
Primary Citation	Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease. Jiang, Y., Andrews, S.W., Condroski, K.R., Buckman, B., Serebryany, V., Wenglowsky, S., Kennedy, A.L., Madduru, M.R., Wang, B., Lyon, M., Doherty, G.A., Woodard, B.T., Lemieux, C., Do, M.G., Zhang, H., Ballard, J., Vigers, G., Brandhuber, B.J., Stengel, P., Josey, J.A., Beigelman, L., Blatt, L., Seiwert, S.D. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2013-05-20
Resolution	2.300
CATH Insert Date	01 Sep, 2013

PDB Images (9)

Image of CATH 4ktc

4ktc

PDB 4ktc

Image of CATH 4ktcA

4ktcA

PDB Chain 4ktcA

Image of CATH 4ktcB

4ktcB

PDB Chain 4ktcB

Image of CATH 4ktcC

4ktcC

PDB Chain 4ktcC

Image of CATH 4ktcD

4ktcD

PDB Chain 4ktcD

Image of CATH 4ktcA01

4ktcA01

CATH Domain 4ktcA01

Image of CATH 4ktcA02

4ktcA02

CATH Domain 4ktcA02

Image of CATH 4ktcC01

4ktcC01

CATH Domain 4ktcC01

Image of CATH 4ktcC02

4ktcC02

CATH Domain 4ktcC02

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	02 Sep, 2013	Chopped
B	02 Sep, 2013	Rejected
C	02 Sep, 2013	Chopped
D	02 Sep, 2013	Rejected

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4ktcA01	04 Sep, 2013	2.40.10.120	Assigned
4ktcA02	04 Sep, 2013	2.40.10.10	Assigned
4ktcC01	03 Sep, 2013	2.40.10.120	Assigned
4ktcC02	03 Sep, 2013	2.40.10.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P26662	POLG_HCVJA	Hepatitis C virus (isolate Japanese)	Genome polyprotein
P26662	POLG_HCVJA	Hepatitis C virus (isolate Japanese)	Genome polyprotein