PDB 4i5i

PDB Links
Overview

PDB Information

PDB	4I5I
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	The 2.5 angstrom crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition. Zhao, X., Allison, D., Condon, B., Zhang, F., Gheyi, T., Zhang, A., Ashok, S., Russell, M., MacEwan, I., Qian, Y., Jamison, J.A., Luz, J.G. J.Med.Chem.
Header	Hydrolase
Released	2012-11-28
Resolution	2.500
CATH Insert Date	27 Jan, 2013

PDB Images (7)

Image of CATH 4i5i

4i5i

PDB 4i5i

Image of CATH 4i5iA

4i5iA

PDB Chain 4i5iA

Image of CATH 4i5iB

4i5iB

PDB Chain 4i5iB

Image of CATH 4i5iA01

4i5iA01

CATH Domain 4i5iA01

Image of CATH 4i5iA02

4i5iA02

CATH Domain 4i5iA02

Image of CATH 4i5iB01

4i5iB01

CATH Domain 4i5iB01

Image of CATH 4i5iB02

4i5iB02

CATH Domain 4i5iB02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	28 Jan, 2013	Chopped
B	28 Jan, 2013	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4i5iA01	01 Feb, 2013	3.40.50.1220	Assigned
4i5iA02	01 Feb, 2013	3.30.1600.10	Assigned
4i5iB01	01 Feb, 2013	3.40.50.1220	Assigned
4i5iB02	01 Feb, 2013	3.30.1600.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q96EB6	SIR1_HUMAN	Homo sapiens	NAD-dependent protein deacetylase sirtuin-1
Q96EB6	SIR1_HUMAN	Homo sapiens	NAD-dependent protein deacetylase sirtuin-1