CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1220 | TPP-binding domain |
Domain Context
CATH Clusters
| Superfamily | TPP-binding domain |
| Functional Family | NAD-dependent histone deacetylase sirtuin-1 |
Enzyme Information
| 3.5.1.- |
In linear amides.
based on mapping to UniProt Q96EB6
|
UniProtKB Entries (1)
| Q96EB6 |
SIR1_HUMAN
Homo sapiens
NAD-dependent protein deacetylase sirtuin-1
|
PDB Structure
| PDB | 4I5I |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The 2.5 angstrom crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.
J.Med.Chem.
|