Design and synthesis of potent, orally efficacious hydroxyethylamine derived beta-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
Dineen, T.A., Weiss, M.M., Williamson, T., Acton, P., Babu-Khan, S., Bartberger, M.D., Brown, J., Chen, K., Cheng, Y., Citron, M., Croghan, M.D., Dunn, R.T., Esmay, J., Graceffa, R.F., Harried, S.S., Hickman, D., Hitchcock, S.A., Horne, D.B., Huang, H., Imbeah-Ampiah, R., Judd, T., Kaller, M.R., Kreiman, C.R., La, D.S., Li, V., Lopez, P., Louie, S., Monenschein, H., Nguyen, T.T., Pennington, L.D., San Miguel, T., Sickmier, E.A., Vargas, H.M., Wahl, R.C., Wen, P.H., Whittington, D.A., Wood, S., Xue, Q., Yang, B.H., Patel, V.F., Zhong, W.
J.Med.Chem.