CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Beta-secretase 1

Enzyme Information

3.4.23.46
Memapsin 2.
based on mapping to UniProt P56817
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
-!- Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

P56817
BACE1_HUMAN
Homo sapiens
Beta-secretase 1

PDB Structure

PDB 4DI2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design and synthesis of potent, orally efficacious hydroxyethylamine derived beta-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
Dineen, T.A., Weiss, M.M., Williamson, T., Acton, P., Babu-Khan, S., Bartberger, M.D., Brown, J., Chen, K., Cheng, Y., Citron, M., Croghan, M.D., Dunn, R.T., Esmay, J., Graceffa, R.F., Harried, S.S., Hickman, D., Hitchcock, S.A., Horne, D.B., Huang, H., Imbeah-Ampiah, R., Judd, T., Kaller, M.R., Kreiman, C.R., La, D.S., Li, V., Lopez, P., Louie, S., Monenschein, H., Nguyen, T.T., Pennington, L.D., San Miguel, T., Sickmier, E.A., Vargas, H.M., Wahl, R.C., Wen, P.H., Whittington, D.A., Wood, S., Xue, Q., Yang, B.H., Patel, V.F., Zhong, W.
J.Med.Chem.