PDB 2r4f

PDB Information

PDB2R4F
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.
Pfefferkorn, J.A., Choi, C., Larsen, S.D., Auerbach, B., Hutchings, R., Park, W., Askew, V., Dillon, L., Hanselman, J.C., Lin, Z., Lu, G.H., Robertson, A., Sekerke, C., Harris, M.S., Pavlovsky, A., Bainbridge, G., Caspers, N., Kowala, M., Tait, B.D.
J.Med.Chem.
HeaderOxidoreductase
Released2007-08-31
Resolution1.700
CATH Insert Date01 May, 2008

PDB Images (17)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 01 May, 2008 Chopped
B 01 May, 2008 Chopped
C 01 May, 2008 Chopped
D 01 May, 2008 Chopped

CATH Domains (12)

Domain ID Date inserted into CATH Superfamily CATH Status
2r4fA01 02 May, 2008 1.10.3270.10 Assigned
2r4fA02 02 May, 2008 3.90.770.10 Assigned
2r4fA03 02 May, 2008 3.30.70.420 Assigned
2r4fB01 02 May, 2008 1.10.3270.10 Assigned
2r4fB02 02 May, 2008 3.90.770.10 Assigned
2r4fB03 02 May, 2008 3.30.70.420 Assigned
2r4fC01 02 May, 2008 1.10.3270.10 Assigned
2r4fC02 02 May, 2008 3.90.770.10 Assigned
2r4fC03 02 May, 2008 3.30.70.420 Assigned
2r4fD01 02 May, 2008 1.10.3270.10 Assigned
2r4fD02 02 May, 2008 3.90.770.10 Assigned
2r4fD03 02 May, 2008 3.30.70.420 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P04035 HMDH_HUMAN Homo sapiens 3-hydroxy-3-methylglutaryl-coenzyme A reductase
P04035 HMDH_HUMAN Homo sapiens 3-hydroxy-3-methylglutaryl-coenzyme A reductase
P04035 HMDH_HUMAN Homo sapiens 3-hydroxy-3-methylglutaryl-coenzyme A reductase
P04035 HMDH_HUMAN Homo sapiens 3-hydroxy-3-methylglutaryl-coenzyme A reductase