PDB Information

PDB2A4G
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHepatitis C virus
Primary Citation
Hepatitis C virus NS3-4a serine protease inhibitors. SAR of P2' moiety with improved potency.
Arasappan, A., Njoroge, F.G., Chan, T.Y., Bennett, F., Bogen, S.L., Chen, K., Gu, H., Hong, L., Jao, E., Liu, Y.T., Lovey, R.G., Parekh, T., Pike, R.E., Pinto, P., Santhanam, B., Venkatraman, S., Vaccaro, H., Wang, H., Yang, X., Zhu, Z., Mckittrick, B., Saksena, A.K., Girijavallabhan, V., Pichardo, J., Butkiewicz, N., Ingram, R., Malcolm, B., Prongay, A.J., Yao, N., Marten, B., Madison, V., Kemp, S., Levy, O., Lim-Wilby, M., Tamura, S., Ganguly, A.K.
Bioorg.Med.Chem.Lett.
HeaderViral Protein
Released2005-06-28
Resolution2.500
CATH Insert Date14 Jul, 2006

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 14 Jul, 2006 Chopped
B 14 Jul, 2006 Rejected
C 14 Jul, 2006 Chopped
D 14 Jul, 2006 Rejected

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
2a4gA01 15 Oct, 2006 2.40.10.120 Assigned
2a4gA02 15 Oct, 2006 2.40.10.10 Assigned
2a4gC01 16 Oct, 2006 2.40.10.120 Assigned
2a4gC02 16 Oct, 2006 2.40.10.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P26664 POLG_HCV1 Hepatitis C virus (isolate 1) Genome polyprotein
P26664 POLG_HCV1 Hepatitis C virus (isolate 1) Genome polyprotein
Q9QP61 Q9QP61_9HEPC Hepatitis C virus subtype 1b Genome polyprotein
Q9QP61 Q9QP61_9HEPC Hepatitis C virus subtype 1b Genome polyprotein