CATH Domain: 1k4cA02 XML data for domain: 1k4cA02

Molscript image for 1k4cA02
1k4cA02
PDB coordinates for domain 1k4cA02

PDB 1k4c, Chain A, Domain 2

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.60 Sandwich
2.60.40 Immunoglobulin-like
2.60.40.10 Immunoglobulins Gene3D
2.60.40.10.12
2.60.40.10.12.1
2.60.40.10.12.1.3
2.60.40.10.12.1.3.1
2.60.40.10.12.1.3.1.4

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Segment boundaries for domain 1k4cA02

Chopping figure for domain 1k4cA02
DomainStart PDB ResidueStop PDB Residue
1k4cA01 1 118
1k4cA02 119 217

Structural Neighbourhood (121 entries)

There are 121 matching structural neighberhood comparisons for CATH ID 2.60.40.10.12.1.3.1.4 (SIMAX score < 5)

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Displaying entries 1 to 121 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1seqH02 95.67 Rattus norvegicusIghg protein 2.60.40.10 98 82 97 0.78 0.80
2vxvH02 93.75 2.60.40.10 101 65 98 1.07 1.09
1q72H02 93.57 2.60.40.10 89 83 89 1.04 1.16
1fv1B02 88.91 HLA class II histocompatibility antigen, DR beta 5 chainMajor histocompatibility complex, class IIType I diabetes mellitusAutoimmune thyroid diseaseIntestinal immune network for IgA production 2.60.40.10 98 18 95 2.64 2.75
1q0xL02 88.89 Mus musculusIg lambda-1 chain V regionProtein binding 2.60.40.10 100 24 96 1.89 1.97
1mcpH02 88.70 Mus musculusIg heavy chain V region M603 2.60.40.10 99 24 96 2.40 2.48
3dbxA02 88.32 CD1-2 antigenGallus gallus 2.60.40.10 99 18 93 2.25 2.40
1dn0D02 88.18 2.60.40.10 94 27 88 1.92 2.16
1l6xA02 87.91 Ig gamma-1 chain C regionHomo sapiensProtein bindingAntigen binding 2.60.40.10 106 31 92 2.06 2.23
1uvqA02 87.45 2.60.40.10 99 27 96 2.14 2.21
1ow0A02 86.67 Homo sapiensProtein bindingIg alpha-1 chain C region 2.60.40.10 109 24 90 1.87 2.06
1o0vA01 86.50 Homo sapiensIg epsilon chain C region 2.60.40.10 102 21 93 2.38 2.56
1l6xA01 86.13 Ig gamma-1 chain C regionHomo sapiensProtein bindingAntigen binding 2.60.40.10 100 23 92 1.97 2.14
1hxmB02 86.00 Homo sapiensT-cell receptor gamma-2 chain C region 2.60.40.10 105 19 91 2.15 2.35
3g08A02 85.60 Antigen-presenting glycoprotein CD1d1Endogenous lipid antigen bindingPositive thymic T cell selectionAntigen processing and presentation, exogenous lipid antigen via MHC class IbProtein binding 2.60.40.10 88 18 86 2.07 2.38
1t7vA02 85.57 Cell adhesionHomo sapiensZinc-alpha-2-glycoprotein 2.60.40.10 90 18 88 2.58 2.90
1je6A02 85.31 Response to heatMHC class I polypeptide-related sequence BGamma-delta T cell activationImmune response-activating cell surface receptor signaling pathwayResponse to retinoic acid 2.60.40.10 89 15 85 2.13 2.48
3fruA02 85.14 IgG receptor FcRn large subunit p51Beta-2-microglobulin bindingRattus norvegicusHumoral immune responseIgG receptor activity 2.60.40.10 92 15 89 2.29 2.55
1u58A02 85.10 Murine cytomegalovirus (strain K181)Immunoevasin 2.60.40.10 100 13 92 2.72 2.96
3h9yB01 85.07 Homo sapiensIg epsilon chain C region 2.60.40.10 101 21 94 2.47 2.63
3h9yA02 84.97 Homo sapiensIg epsilon chain C region 2.60.40.10 108 22 91 2.38 2.60
2bnuB02 84.87 T-cell receptor beta-1 chain C regionHomo sapiensProtein binding 2.60.40.10 126 25 78 1.82 2.32
2fbjH02 84.54 Mus musculusIg heavy chain V region J539 2.60.40.10 73 27 71 2.48 3.46
2bc4D02 84.37 Major histocompatibility complex, class IIType I diabetes mellitusAutoimmune thyroid diseaseIntestinal immune network for IgA productionAllograft rejection 2.60.40.10 107 25 88 3.64 4.10
1dr9A02 83.57 Type I diabetes mellitusIntestinal immune network for IgA productionAutoimmune thyroid diseaseAllograft rejectionT-lymphocyte activation antigen CD80 2.60.40.10 95 16 88 2.95 3.32
2bc4A02 83.52 HLA class II histocompatibility antigen, DM alpha chainHomo sapiensProtein binding 2.60.40.10 109 20 87 2.80 3.21
1mh5B02 82.67 2.60.40.10 52 100 52 0.51 0.97
1hxmA02 82.54 2.60.40.10 85 21 85 3.18 3.70
2rikA01 82.21 TitinOryctolagus cuniculus 2.60.40.10 96 17 83 2.99 3.57
1ow0A01 82.16 Homo sapiensProtein bindingIg alpha-1 chain C region 2.60.40.10 100 23 93 3.17 3.41
2ec8A03 82.09 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Acute myeloid leukemiaProtein binding 2.60.40.10 104 13 91 3.38 3.70
1vcaA01 81.62 Vascular cell adhesion protein 1MicrovillusPositive regulation of T cell proliferationHeterophilic cell-cell adhesionFilopodium 2.60.40.10 89 19 81 3.55 4.34
2ec8A04 81.34 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Extracellular spaceAcute myeloid leukemia 2.60.40.10 100 11 92 3.42 3.72
2bk8A00 81.34 Structural constituent of muscleCalcium ion bindingTelethonin bindingSarcomere organizationActin filament binding 2.60.40.10 97 12 83 3.29 3.92
2v44A01 80.93 Prion diseasesNeural cell adhesion moleculeNeuron cell-cell adhesionPlasma membraneNeural cell adhesion molecule 2 2.60.40.10 94 11 83 3.23 3.85
2a38B01 80.72 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 99 12 86 3.15 3.63
1fhgA00 80.71 TelokinMeleagris gallopavo 2.60.40.10 102 11 85 3.22 3.78
1p53A01 80.24 Leukocyte migrationAdhesion to symbiontHeterophilic cell-cell adhesionRegulation of leukocyte mediated cytotoxicityT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 2.60.40.10 98 11 87 3.62 4.12
2ifgA02 80.18 High affinity nerve growth factor receptorIntegral to plasma membraneTransmembrane receptor protein tyrosine kinase activityHomo sapiens 2.60.40.10 90 15 83 3.21 3.83
2rikA03 80.12 TitinOryctolagus cuniculus 2.60.40.10 92 15 80 2.99 3.70
2gy5A04 80.06 MicrovillusCell surfaceTransmembrane receptor protein tyrosine kinase signaling pathwaySignal transductionProtein binding 2.60.40.10 99 13 87 3.70 4.21
3b43A02 80.04 TitinOryctolagus cuniculus 2.60.40.10 97 12 84 2.94 3.46
2rikA02 80.01 TitinOryctolagus cuniculus 2.60.40.10 95 10 82 3.42 4.13
2j8hA01 79.86 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 97 11 84 3.18 3.75
1g1cA00 79.66 Structural constituent of muscleCalcium ion bindingTelethonin bindingSarcomere organizationActin filament binding 2.60.40.10 98 10 85 3.40 3.96
1gsmA02 79.60 Membrane fractionMucosal vascular addressin cell adhesion molecule 1Intestinal immune network for IgA productionCell adhesionHomo sapiens 2.60.40.10 116 7 80 3.32 4.14
1itbB03 79.47 Platelet-derived growth factor receptor bindingIntegral to plasma membraneHematopoietic cell lineageInterleukin 1 receptor, type IInterleukin-1-mediated signaling pathway 2.60.40.10 112 19 84 3.57 4.21
1koaA03 79.14 Caenorhabditis elegansProtein ZK617.1b, partially confirmed by transcript evidenceLocomotionReproduction 2.60.40.10 96 11 79 2.91 3.65
1nkrA01 78.99 Integral to plasma membraneReceptor activityHomo sapiensNatural killer cell inhibitory signaling pathwayImmune response 2.60.40.10 97 9 88 4.19 4.71
1gl4B00 78.87 Chondrocyte differentiationCardiac muscle tissue developmentCartilage development involved in endochondral bone morphogenesisProtein localizationBrain development 2.60.40.10 89 13 79 3.26 4.09
1iamA02 78.77 Leukocyte migrationAdhesion to symbiontHeterophilic cell-cell adhesionRegulation of leukocyte mediated cytotoxicityT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 2.60.40.10 102 14 89 3.83 4.29
2ec8A05 78.62 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Extracellular spaceAcute myeloid leukemia 2.60.40.10 81 18 78 3.40 4.32
2c5dC01 78.55 Integral to plasma membraneTransmembrane receptor protein tyrosine kinase activityHomo sapiensTyrosine-protein kinase receptor UFOSignal transduction 2.60.40.10 104 15 84 3.13 3.70
1cs6A04 78.46 Cell adhesion molecule bindingContactin 2Neuron cell-cell adhesionGallus gallusContactin-2 2.60.40.10 90 13 78 3.20 4.06
2q8bH01 78.41 2.60.40.10 112 8 70 3.01 4.27
1t0pB00 78.29 Integral to plasma membraneIntercellular adhesion molecule 3Homo sapiensIntercellular adhesion molecule 3Cell adhesion molecules (CAMs) 2.60.40.10 86 6 80 3.70 4.58
1mfaH01 78.26 2.60.40.10 97 11 71 3.49 4.87
1pewA00 78.13 Ig lambda chain V-VI region SUTHomo sapiens 2.60.40.10 108 12 78 3.40 4.32
3cafA01 78.11 Cell surfacePathways in cancerNucleusPositive regulation of cell proliferationFibroblast growth factor binding 2.60.40.10 96 10 79 3.57 4.47
1iilG02 78.04 Cell surfacePathways in cancerNucleusPositive regulation of cell proliferationFibroblast growth factor binding 2.60.40.10 107 10 76 3.75 4.89
1vjjA04 77.95 Calcium ion bindingHair follicle morphogenesisGTP bindingExtrinsic to internal side of plasma membraneTransglutaminase 3 [EC:2.3.2.13] 2.60.40.10 97 6 89 4.11 4.57
1dceA02 77.94 Rattus norvegicusRab geranylgeranyltransferase activityProtein geranylgeranyltransferase type II [EC:2.5.1.60]Geranylgeranyl transferase type-2 subunit alpha 2.60.40.1130 103 10 82 3.87 4.69
1rhfA01 77.91 Integral to plasma membraneTyrosine-protein kinase receptor TYRO3Cell adhesionTYRO3 protein tyrosine kinase 3 [EC:2.7.10.1]Signal transduction 2.60.40.10 89 12 80 3.88 4.80
2nqcA00 77.89 Plasma membraneFilamin-CHomo sapiens 2.60.40.10 97 9 86 4.25 4.89
1ogaD02 77.83 Homo sapiensT-cell receptor alpha chain C region 2.60.40.10 90 10 79 3.79 4.75
1ogaD01 77.81 Homo sapiensT-cell receptor alpha chain C region 2.60.40.10 109 12 76 3.42 4.49
2dm2A00 77.79 NucleusHomo sapiensPalladinActin filamentMuscle alpha-actinin binding 2.60.40.10 110 15 79 3.79 4.79
1waaC00 77.78 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 93 9 79 3.40 4.26
1yc7A00 77.77 2.60.40.10 116 13 74 3.65 4.92
1f97A01 77.74 Mus musculusEpithelial cell differentiationJunctional adhesion molecule ACell adhesionTight junction 2.60.40.10 102 14 81 3.57 4.39
1cs6A03 77.71 Cell adhesion molecule bindingContactin 2Neuron cell-cell adhesionGallus gallusContactin-2 2.60.40.10 98 14 81 3.31 4.05
1cs6A02 77.61 Cell adhesion molecule bindingContactin 2Neuron cell-cell adhesionGallus gallusContactin-2 2.60.40.10 89 13 77 3.54 4.55
2ialA01 77.57 Homo sapiensT-cell receptor alpha chain C region 2.60.40.10 108 16 77 3.28 4.22
2vxtH01 77.43 2.60.40.10 113 10 70 3.22 4.55
2cqvA00 77.40 Myosin light chain kinase activityProtein phosphorylationHomo sapiensMyosin light chain kinase, smooth muscle 2.60.40.10 114 16 75 3.29 4.36
3hn3A02 77.36 Beta-glucuronidaseGlycosaminoglycan degradationGlycosaminoglycan catabolic processMetabolic pathwaysStarch and sucrose metabolism 2.60.40.320 103 5 78 3.31 4.21
2otuA00 77.36 2.60.40.10 115 9 73 3.25 4.45
2r2cB00 77.34 Porphyromonas gingivalis28 kDa outer membrane protein Omp28 2.60.40.320 107 12 82 4.03 4.90
3bp6A00 77.28 Mus musculusExternal side of plasma membraneProgrammed cell death protein 1Programmed cell death protein 1T cell receptor signaling pathway 2.60.40.10 111 11 74 3.41 4.56
3cmgA04 77.27 Putative beta-galactosidaseBacteroides fragilis NCTC 9343 2.60.40.1560 87 10 79 3.98 4.99
2v44A02 77.24 Prion diseasesNeural cell adhesion moleculePlasma membraneNeuron cell-cell adhesionNeural cell adhesion molecule 2 2.60.40.10 93 8 82 3.45 4.17
1rhfA02 77.24 Integral to plasma membraneTyrosine-protein kinase receptor TYRO3Cell adhesionTYRO3 protein tyrosine kinase 3 [EC:2.7.10.1]Signal transduction 2.60.40.10 84 19 79 3.78 4.74
1mjuH01 77.23 2.60.40.10 115 10 72 3.18 4.41
2ak4D01 77.15 Homo sapiensT-cell receptor alpha chain C region 2.60.40.10 114 14 75 3.68 4.88
1x9qA01 77.05 2.60.40.10 111 6 76 3.61 4.71
1bihA04 76.99 Hyalophora cecropiaHemolin 2.60.40.10 88 17 78 3.49 4.43
1kgcE01 76.85 T-cell receptor beta-1 chain C regionHomo sapiensProtein binding 2.60.40.10 112 12 73 3.59 4.90
1u3hA00 76.83 Mus musculusTRAV14-3 2.60.40.10 110 10 76 3.61 4.73
1iamA01 76.78 Leukocyte migrationAdhesion to symbiontHeterophilic cell-cell adhesionRegulation of leukocyte mediated cytotoxicityT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 2.60.40.10 83 9 79 3.76 4.71
1jz7A02 76.66 Galactose metabolismSphingolipid metabolismOther glycan degradationMetabolic pathwaysLactose catabolic process 2.60.40.320 114 10 79 3.62 4.53
2r39A00 76.60 Vibrio parahaemolyticusFixG-related protein 2.60.40.10 107 8 88 4.28 4.82
1bihA03 76.56 Hyalophora cecropiaHemolin 2.60.40.10 100 8 87 4.33 4.98
2q0zX03 76.53 ATP-dependent helicase activityPre-mRNA-splicing helicase BRR2 [EC:3.6.1.-]Protein bindingU5 small nuclear ribonucleoprotein 200 kDa helicaseU5 snRNP 2.60.40.150 113 5 77 3.76 4.83
1ej6A05 76.52 Mammalian orthoreovirus 3 DearingOuter capsid protein lambda-2 2.60.40.10 95 3 80 3.90 4.83
1ugnA01 76.40 Homo sapiensLeukocyte immunoglobulin-like receptor subfamily B member 1Integral to membraneResponse to virusProtein phosphatase 1 binding 2.60.40.10 95 4 88 4.44 5.00
1neuA00 76.36 Rattus norvegicusMyelin protein P0 2.60.40.10 115 17 71 3.14 4.40
1witA00 76.32 Caenorhabditis elegansProtein ZK617.1b, partially confirmed by transcript evidenceLocomotionReproduction 2.60.40.10 93 12 85 4.26 4.96
1fnfA01 76.28 FibronectinER-Golgi intermediate compartmentPeptide cross-linkingFibrinogen complexSubstrate adhesion-dependent cell spreading 2.60.40.10 94 9 78 3.68 4.67
1bihA01 76.24 Hyalophora cecropiaHemolin 2.60.40.10 97 10 84 4.05 4.77
1cvrA03 76.22 Gingipain R [EC:3.4.22.37]Porphyromonas gingivalisGingipain R2 2.60.40.10 83 12 79 3.76 4.71
1tvdA00 76.19 Homo sapiensHDV103S1 2.60.40.10 116 14 74 3.58 4.83
1fnfA02 76.17 FibronectinPeptide cross-linkingER-Golgi intermediate compartmentFibrinogen complexSubstrate adhesion-dependent cell spreading 2.60.40.10 87 6 77 3.78 4.86
2nw2A01 76.07 TRA@ proteinHomo sapiens 2.60.40.10 103 3 77 3.52 4.53
1hxmB01 75.86 Homo sapiensT-cell receptor gamma-2 chain C region 2.60.40.10 125 16 69 3.40 4.89
1pkoA00 75.64 Rattus norvegicusMyelin-oligodendrocyte glycoproteinPositive regulation of MyD88-dependent toll-like receptor signaling pathway 2.60.40.10 123 10 71 3.52 4.92
1lp9E01 75.64 2.60.40.10 113 16 75 3.36 4.47
1olzA03 75.60 Anti-apoptosisReceptor bindingSemaphorin-4DReceptor activityCell adhesion 2.60.40.10 89 13 73 3.33 4.52
1nctA00 75.59 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 98 8 85 4.23 4.93
1l6zA02 75.59 Mus musculusCarcinoembryonic antigen-related cell adhesion molecule 1 2.60.40.10 96 14 81 3.88 4.74
3bfoA00 75.53 T cell receptor signaling pathwayPositive regulation of T cell cytokine productionActivation of NF-kappaB-inducing kinase activityPositive regulation of interleukin-2 productionNucleus 2.60.40.10 85 11 79 3.86 4.84
2aepL01 75.52 2.60.40.10 119 7 68 3.39 4.98
1kgcD01 75.52 Homo sapiensT-cell receptor alpha chain C region 2.60.40.10 111 7 74 3.70 4.95
1cs6A01 75.51 Cell adhesion molecule bindingContactin 2Neuron cell-cell adhesionGallus gallusContactin-2 2.60.40.10 105 9 79 3.70 4.68
2ny1B02 75.12 Zinc ion bindingMaintenance of protein location in cellT-cell surface glycoprotein CD4Signal transductionT cell receptor signaling pathway 2.60.40.10 75 13 73 3.65 4.95
2hp4A00 74.68 T-cell surface glycoprotein CD8 alpha chainCD8A antigen, alpha polypeptideHematopoietic cell lineagePrimary immunodeficiencyHomo sapiens 2.60.40.10 112 7 72 3.44 4.76
2gysA03 74.56 Jak-STAT signaling pathwayGranulocyte macrophage colony-stimulating factor receptor complexCytokine receptor common subunit betaCytokine receptor common subunit betaApoptosis 2.60.40.10 86 5 74 3.63 4.86
1qfoC00 74.37 Mus musculusSialoadhesinProtein binding 2.60.40.10 114 9 74 3.54 4.75
1eh9A03 74.19 Sulfolobus solfataricusMalto-oligosyltrehalose trehalohydrolase 2.60.40.10 87 4 72 3.54 4.87
2jllA04 74.04 Prion diseasesNeural cell adhesion moleculePlasma membraneNeuron cell-cell adhesionNeural cell adhesion molecule 2 2.60.40.10 91 5 79 3.90 4.89
1im3D00 73.24 Unique short US2 glycoproteinHuman herpesvirus 5 strain AD169 2.60.40.1200 95 4 89 4.22 4.69
1bihA02 73.15 Hyalophora cecropiaHemolin 2.60.40.10 106 11 75 3.72 4.93
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Displaying entries 1 to 121 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1k4cA02
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSSWPSETV
TCNVAHPASSTKVDKKIVP
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1k4cA02
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSSWPSETV
TCNVAHPASSTKVDKKIVP
BLAST against CATH

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Domain History Events (3)

Set cath from cathlist by auto on 05 Mar 2006 18:37

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Flow stage update by auto on 05 Mar 2006 18:37

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Insertion by auto on 05 Mar 2006 17:01

PDB chopped based on information from the domall file "/usr/local/cvs/source/lists/CathDomall"