Homologous Superfamily: 3.40.1190.10

Molscript image for 2x5oA02
Representative domain: 2x5oA02
PDB coordinates for domain 2x5oA02

Classification Lineage (3.40.1190.10)

CATH CodeLevel DescriptionLinks
3 Alpha Beta
3.40 3-Layer(aba) Sandwich
3.40.1190 UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
3.40.1190.10 Gene3D

Summary of Non-Redundant Representatives
- - - - 8 10 11 46 50

S35 Family Entries in Homologous Superfamily 3.40.1190.10 (8)

CATH Level CATH code Representative Domain Representative Keywords Representative Thumbnail Number of Domains
3.40.1190.10.1 2x5oA02 UDP-N-acetylmuramoylalanine--D-glutamate ligaseD-Glutamine and D-glutamate metabolismUDP-N-acetylmuramoylalanine-D-glutamate ligase activityPeptidoglycan biosynthesisUDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase. Molscript image for 2x5oA02 15
3.40.1190.10.2 1gqyB02 UDP-N-acetylmuramate--L-alanine ligaseD-Glutamine and D-glutamate metabolismUDP-N-acetylmuramate--L-alanine ligase.Haemophilus influenzaeUDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8] Molscript image for 1gqyB02 10
3.40.1190.10.3 1e8cA02 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]Peptidoglycan biosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activityProtein bindingLysine biosynthesis Molscript image for 1e8cA02 10
3.40.1190.10.4 1gg4A02 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activityUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D -alanyl-D-alanine ligase [EC:6.3.2.10]Peptidoglycan biosynthesisUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligaseLysine biosynthesis Molscript image for 1gg4A02 2
3.40.1190.10.5 3eagA02 UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase [EC:6.3.2.-]Neisseria meningitidis serogroup BAcid--D-amino-acid ligases (peptide synthases).UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase Molscript image for 3eagA02 2
3.40.1190.10.6 1w78A01 Tetrahydrofolylpolyglutamate synthase activityDihydrofolate synthase.Tetrahydrofolate synthase.Folate biosynthesisProtein binding Molscript image for 1w78A01 2
3.40.1190.10.7 1j6uA02 D-Glutamine and D-glutamate metabolismUDP-N-acetylmuramate--L-alanine ligase.UDP-N-acetylmuramate--L-alanine ligaseThermotoga maritimaUDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8] Molscript image for 1j6uA02 1
3.40.1190.10.8 2gc5A01 Tetrahydrofolate synthase.Lactobacillus caseiFolylpolyglutamate synthase Molscript image for 2gc5A01 8

Close Structural Clusters 3.40.1190.10 (< 5Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID Example Domain Domains in Cluster Structural Alignment (Core) Structural Alignment (Expanded)
00003.00040.01190.00010/SSG5/1 1e8cA02 5
00003.00040.01190.00010/SSG5/2 1gqyB02 3


Distant Structural Clusters 3.40.1190.10 (< 9Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID Example Domain Domains in Cluster Structural Alignment (Core) Structural Alignment (Expanded)
00003.00040.01190.00010/SSGA9/1 2x5oA02 2


The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:
  • Multiple alignments for each functional family
  • Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
  • Detailed functional information on diversity and conservation within Functional families
  • Multi-domain architectures
In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:
http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.40.1190.10