×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Protein tyrosine phosphatase superfamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1817
3D
3sr9A01 - 80.3
2
1741
3D
3sr9A02 - 89.0
3
1027 - - 87.1
4
853
3D
2nt2C00 - 94.5
5
798
3D
2c7sA00 - 65.7
6
675
3D
1oheA02 - 89.8
7
546
3D
1yfoB00 - 86.1
9
536
3D
2nz6A00 - 91.4
25
526
3D
6cwvA00 - 78.7
8
511 - - 92.9
10
489 - - 77.2
12
477
3D
5mmzB00 - 85.6
11
471
3D
1mkpA00 - 76.7
18
408
3D
6mddB03 - 78.7
13
369
3D
2nlkA02 - 92.3
16
363
3D
5h08A00 - 71.3
15
350
3D
3ezzF00 - 76.3
14
343 - - 63.4
17
339
3D
2qepB00 - 89.2
20
333
3D
6h8sA00 - 82.1
19
327 - - 63.4
21
303
3D
1p15B00 - 85.5
22
283
3D
2jjdF02 - 70.3
23
274
3D
4s0gA00 - 79.1
24
253
3D
2q47B00 - 84.5
26
241
3D
4iczA00 - 91.3
29
235
3D
5bzzD01 - 84.2
28
227
3D
2oudA00 - 87.5
27
227 - - 79.2
30
222
3D
2bzlA00 - 81.8
31
219
3D
1oheA01 - 59.6
33
214
3D
1yguB01 - 71.7
32
214 - - 92.7
34
180
3D
1wchA00 - 47.5
35
178 - - 98.2
36
177
3D
2r0bA00 - 96.6
37
176
3D
4hrfD00 - 88.4
45
174
3D
4j51B00 - 94.3
39
165
3D
2gjtB00 - 61.1
40
164
3D
2c46D00 - 91.2
38
162 - - 92.8
42
160
3D
1yguB02 - 92.1
41
157
3D
4ikcA00 - 60.0
44
150
3D
4jmkB00 - 71.5
43
150 - - 71.5
46
149
3D
1fq1A00 - 95.4
47
140 - - 73.9
48
137
3D
4wohA01 - 81.8
49
136
3D
2esbA00 - 82.3
50
Predicted
131
3D
4yr8H00 - 62.2
51
125 - - 80.8
52
120
3D
1yz4B01 - 87.3
53
113 - - 80.3
54
113
3D
4rkkC02 - 85.8
55
107 - - 77.2
56
102
3D
4ki9A00 - 93.7
59
100
3D
2pq5D00 - 42.0
57
98
3D
2g6zC00 - 72.1
60
94
3D
3rgqA00 - 93.3
58
92 - - 72.5
64
81
3D
4nyhC00 - 92.6
65
81
3D
3f81B00 - 64.2
63
80
3D
4ercB00 - 94.9
61
79 - - 56.8
62
77 - - 92.5
66
73 - - 73.9
67
71 - - 83.4
69
65
3D
4pyhA01 - 71.9
71
65
3D
4d3rA00 - 73.6
68
63 - - 75.6
70
61 - - 79.2
72
56 - - 61.1
75
56
3D
4kyrA00 - 73.6
74
55 - - 55.2
73
55 - - 78.6
76
54 - - 74.8
77
53 - - 38.0
78
52 - - 66.8
79
51 - - 76.8
80
45 - - 92.6
81
44 - - 71.6
82
42 - - 94.0
86
42
3D
3s4oB00 - 92.1
83
41 - - 77.9
85
41 - - 76.7
84
41 - - 88.6
88
39 - - 87.6
87
39 - - 39.2
89
36 - - 19.9
90
35 - - 81.6
94
32
3D
2j17B00 - 79.6
92
31 - - 83.0
91
31 - - 52.3
93
30 - - 71.0
95
27 - - 79.1
96
27 - - 75.3
97
26 - - 70.6
107
26
3D
5y16B00 - 83.0
98
26 - - 86.4
99
25 - - 62.7
100
24 - - 71.7
105
24
3D
5tsrC00 - 24.0
102
23 - - 96.2
101
23 - - 76.1
103
23 - - 67.0
157
23
3D
5z5bC00 - 93.6
104
22 - - 78.9
106
21 - - 78.7
108
20 - - 20.9
109
19 - - 74.2
110
18 - - 75.5
114
17 - - 88.0
112
17 - - 73.8
113
17 - - 15.4
111
17 - - 73.6
115
16 - - 81.2
117
16 - - 79.7
116
16 - - 80.7
121
15 - - 80.2
118
15 - - 86.4
120
15 - - 84.2
119
15 - - 55.6
123
14 - - 86.8
124
14 - - 19.1
122
14 - - 58.9
126
13 - - 75.7
125
13 - - 8.8
127
13 - - 78.3
132
12 - - 47.0
129
12 - - 83.7
130
12 - - 94.9
128
12 - - 88.9
131
12 - - 66.0
133
12 - - 83.3
138
11 - - 6.8
146
11 - - 87.6
137
11 - - 1.6
149
11 - - 97.6
134
11 - - 87.2
143
11 - - 34.2
141
11 - - 42.6
135
11 - - 19.8
142
Pyp1
11 - - 76.9
139
11 - - 12.2
136
11 - - 9.7
147
11 - - 36.6
148
11 - - 82.3
140
11 - - 10.8
145
11 - - 96.3
144
11 - - 75.0
151
10 - - 44.3
150
10 - - 81.9
152
10 - - 67.5
153
9 - - 0.6
156
9 - - 35.3
154
9 - - 9.3
155
9 - - 10.1
158
9 - - 33.5
166
8 - - 5.0
184
8
3D
3emuA00 - 15.9
188
8
3D
1v3aA00 - 52.0
159
8 - - 18.8
163
8 - - 13.9
161
8 - - 86.7
162
8 - - 9.2
165
8 - - 20.8
160
8 - - 36.4
177
8
3D
4r0sA00 - 2.9
164
8 - - 8.9
171
7 - - 2.4
185
7 - - 88.1
173
7 - - 7.8
169
7 - - 0.0
180
7 - - 7.9
176
7 - - 2.8
179
7 - - 6.8
182
7 - - 11.4
170
7 - - 21.1
181
7 - - 11.9
183
7 - - 15.4
175
7 - - 9.8
168
7 - - 12.8
167
7 - - 39.9
174
7 - - 5.4
172
7 - - 7.8
186
7 - - 71.9
178
7 - - 8.9
198
6 - - 0.7
209
6 - - 81.3
197
6 - - 0.7
192
6 - - 73.9
206
6 - - 2.8
201
6 - - 19.4
247
6
3D
3m4uB00 - 0.0
203
6 - - 1.6
194
6 - - 5.4
211
6 - - 45.5
187
6 - - 72.5
195
6 - - 3.0
190
6 - - 71.5
207
6 - - 3.8
208
6 - - 52.4
199
6 - - 5.5
196
6 - - 3.3
202
6 - - 30.1
191
6 - - 64.3
189
6 - - 71.2
204
6 - - 30.5
193
6 - - 77.0
210
6 - - 68.5
200
AFU_orthologue AFUA_2G02760
6 - - 16.1
205
6 - - 49.5
222
5 - - 10.8
219
5 - - 9.8
228
5 - - 81.0
231
5 - - 83.1
216
5 - - 82.5
227
5 - - 64.2
233
5 - - 91.2
213
5 - - 83.2
225
5 - - 13.2
255
5
3D
3n0aA01 - 23.4
220
5 - - 12.7
224
5 - - 66.7
226
5 - - 78.7
217
5 - - 79.0
218
5 - - 0.0
230
5 - - 81.4
229
5 - - 70.5
212
5 - - 81.6
232
5 - - 39.2
214
5 - - 77.6
221
5 - - 4.8
215
AFU_orthologue AFUA_6G06650
5 - - 72.8
223
5 - - 9.4
264
4 - - 56.1
252
4 - - 2.8
244
4 - - 29.8
265
4 - - 77.4
240
4 - - 24.5
257
4 - - 7.2
245
4 - - 12.8
260
4 - - 33.0
272
4 - - 66.9
258
4 - - 73.9
250
4 - - 24.9
268
4 - - 66.1
236
4 - - 38.5
267
4 - - 42.2
248
4 - - 14.6
262
4 - - 84.5
270
4 - - 91.7
242
4 - - 54.4
239
4 - - 39.8
254
4 - - 39.7
243
4 - - 65.5
235
4 - - 74.4
241
4 - - 26.4
263
4 - - 71.6
256
4 - - 86.5
261
4 - - 40.4
259
4 - - 58.4
234
4 - - 14.6
271
4 - - 41.4
249
4 - - 74.5
269
4 - - 55.7
266
4 - - 81.1
253
4 - - 17.3
238
4 - - 63.5
251
4 - - 10.8
237
4 - - 56.1
246
4 - - 10.8
277
3 - - 61.4
286
3 - - 9.0
301
3 - - 8.5
278
3 - - 60.5
303
3 - - 68.0
289
3 - - 6.0
291
3 - - 0.0
293
3 - - 9.1
296
3 - - 2.9
274
3 - - 18.4
306
3 - - 81.1
281
3 - - 3.1
299
3 - - 4.3
275
3 - - 34.4
283
3 - - 1.6
279
3 - - 7.0
282
3 - - 0.7
295
3 - - 6.7
304
3 - - 70.4
290
3 - - 5.3
288
3 - - 68.9
294
3 - - 66.5
305
3 - - 73.5
287
3 - - 4.8
276
3 - - 56.9
300
Hsp40
3 - - 0.0
273
3 - - 70.8
285
3 - - 1.7
292
3 - - 11.0
280
3 - - 0.0
298
3 - - 0.0
302
3 - - 45.7
284
3 - - 13.2
297
3 - - 0.0
408
2 - - 47.3
355
2 - - 0.0
367
2 - - 4.0
348
2 - - 0.0
374
2 - - 0.0
320
2 - - 42.9
350
2 - - 6.7
407
2 - - 43.7
313
2 - - 15.4
336
2 - - 1.4
325
2 - - 13.1
311
2 - - 29.6
347
2 - - 0.0
396
2 - - 0.0
368
2 - - 0.4
399
2 - - 37.0
354
2 - - 2.9
342
AFU_orthologue AFUA_1G13040
2 - - 0.0
339
2 - - 0.0
381
2 - - 0.0
375
2 - - 2.9
383
2 - - 39.8
402
2 - - 9.8
362
2 - - 34.0
324
2 - - 13.3
370
2 - - 2.5
344
2 - - 0.0
352
2 - - 8.9
378
2 - - 0.0
404
2 - - 38.5
377
2 - - 0.0
309
2 - - 23.0
364
2 - - 32.6
322
2 - - 41.0
386
2 - - 29.8
319
2 - - 37.5
327
2 - - 0.0
391
2 - - 0.7
331
2 - - 0.4
345
2 - - 0.0
316
2 - - 29.3
389
2 - - 8.0
360
2 - - 32.9
372
2 - - 7.5
358
2 - - 20.1
333
2 - - 0.0
405
2 - - 39.0
393
2 - - 0.0
365
2 - - 39.6
340
2 - - 0.0
410
2 - - 37.9
328
2 - - 2.9
400
2 - - 37.8
357
2 - - 15.5
314
2 - - 12.2
369
2 - - 0.5
380
2 - - 0.0
371
2 - - 0.0
409
2 - - 46.4
392
2 - - 4.0
373
2 - - 0.0
385
2 - - 21.4
349
2 - - 3.6
332
2 - - 0.0
397
2 - - 0.0
321
2 - - 38.4
315
2 - - 36.1
346
2 - - 0.0
337
2 - - 2.9
406
2 - - 40.6
323
2 - - 35.9
338
2 - - 0.0
353
2 - - 0.0
310
2 - - 30.1
398
2 - - 1.7
366
2 - - 38.7
384
2 - - 0.9
351
2 - - 1.9
356
2 - - 7.2
363
2 - - 39.2
308
2 - - 33.6
330
2 - - 9.9
361
2 - - 34.4
318
2 - - 39.5
390
2 - - 7.1
379
2 - - 0.0
343
2 - - 0.0
307
2 - - 16.5
401
2 - - 30.9
403
2 - - 36.4
395
2 - - 3.6
317
2 - - 13.4
382
2 - - 0.0
335
2 - - 0.0
411
2 - - 37.6
326
2 - - 0.0
341
2 - - 0.0
329
2 - - 0.0
312
2 - - 35.7
387
2 - - 8.9
376
2 - - 0.0
388
2 - - 0.7
334
2 - - 7.3
359
2 - - 21.1
394
2 - - 0.0
520
1 - - 0.0
611
1 - - 0.0
463
1 - - 0.0
574
1 - - 0.0
548
1 - - 0.0
456
1 - - 0.0
567
1 - - 0.0
603
1 - - 0.0
490
1 - - 0.0
601
1 - - 0.0
418
1 - - 0.0
555
1 - - 0.0
461
1 - - 0.0
430
1 - - 0.0
613
1 - - 0.0
568
1 - - 0.0
503
1 - - 0.0
596
1 - - 0.0
547
1 - - 0.0
511
1 - - 0.0
443
1 - - 0.0
536
1 - - 0.0
479
1 - - 0.0
620
1 - - 0.0
525
1 - - 0.0
441
1 - - 0.0
513
1 - - 0.0
426
1 - - 0.0
435
1 - - 0.0
482
1 - - 0.0
550
1 - - 0.0
417
1 - - 0.0
501
1 - - 0.0
495
1 - - 0.0
487
1 - - 0.0
412
1 - - 0.0
624
1 - - 0.0
583
1 - - 0.0
575
1 - - 0.0
429
1 - - 0.0
581
1 - - 0.0
476
1 - - 0.0
539
1 - - 0.0
542
1 - - 0.0
554
1 - - 0.0
599
1 - - 0.0
570
1 - - 0.0
524
1 - - 0.0
488
1 - - 0.0
494
1 - - 0.0
459
1 - - 0.0
434
1 - - 0.0
562
1 - - 0.0
622
1 - - 0.0
414
1 - - 0.0
619
1 - - 0.0
578
1 - - 0.0
552
1 - - 0.0
609
1 - - 0.0
480
1 - - 0.0
469
1 - - 0.0
544
1 - - 0.0
586
1 - - 0.0
519
1 - - 0.0
471
1 - - 0.0
522
1 - - 0.0
432
1 - - 0.0
449
1 - - 0.0
485
1 - - 0.0
564
1 - - 0.0
473
1 - - 0.0
509
1 - - 0.0
492
1 - - 0.0
577
1 - - 0.0
437
1 - - 0.0
506
1 - - 0.0
593
1 - - 0.0
415
1 - - 0.0
446
1 - - 0.0
558
1 - - 0.0
533
1 - - 0.0
421
1 - - 0.0
572
1 - - 0.0
497
1 - - 0.0
560
1 - - 0.0
516
1 - - 0.0
545
1 - - 0.0
589
1 - - 0.0
423
1 - - 0.0
531
1 - - 0.0
591
1 - - 0.0
527
1 - - 0.0
466
1 - - 0.0
498
1 - - 0.0
557
1 - - 0.0
606
1 - - 0.0
438
1 - - 0.0
453
1 - - 0.0
451
1 - - 0.0
528
1 - - 0.0
616
1 - - 0.0
540
1 - - 0.0
565
1 - - 0.0
484
1 - - 0.0
504
1 - - 0.0
478
1 - - 0.0
452
1 - - 0.0
580
1 - - 0.0
569
1 - - 0.0
444
1 - - 0.0
514
1 - - 0.0
532
1 - - 0.0
585
1 - - 0.0
549
1 - - 0.0
573
1 - - 0.0
464
1 - - 0.0
604
1 - - 0.0
592
1 - - 0.0
477
1 - - 0.0
419
1 - - 0.0
486
1 - - 0.0
571
1 - - 0.0
614
Hsp40
1 - - 0.0
422
1 - - 0.0
460
1 - - 0.0
489
1 - - 0.0
445
1 - - 0.0
416
1 - - 0.0
431
1 - - 0.0
523
1 - - 0.0
600
1 - - 0.0
505
1 - - 0.0
491
1 - - 0.0
427
1 - - 0.0
537
1 - - 0.0
493
1 - - 0.0
546
1 - - 0.0
515
1 - - 0.0
610
1 - - 0.0
521
1 - - 0.0
433
1 - - 0.0
458
1 - - 0.0
472
1 - - 0.0
597
1 - - 0.0
428
1 - - 0.0
551
1 - - 0.0
500
1 - - 0.0
605
1 - - 0.0
623
1 - - 0.0
440
1 - - 0.0
465
1 - - 0.0
584
1 - - 0.0
566
1 - - 0.0
598
1 - - 0.0
621
1 - - 0.0
615
1 - - 0.0
457
1 - - 0.0
510
1 - - 0.0
553
1 - - 0.0
538
1 - - 0.0
590
1 - - 0.0
518
1 - - 0.0
617
1 - - 0.0
455
1 - - 0.0
561
1 - - 0.0
530
1 - - 0.0
420
1 - - 0.0
474
1 - - 0.0
563
1 - - 0.0
508
1 - - 0.0
607
1 - - 0.0
448
1 - - 0.0
556
1 - - 0.0
467
1 - - 0.0
541
1 - - 0.0
413
1 - - 0.0
535
1 - - 0.0
526
1 - - 0.0
582
1 - - 0.0
450
1 - - 0.0
517
1 - - 0.0
618
1 - - 0.0
595
1 - - 0.0
468
1 - - 0.0
496
1 - - 0.0
447
1 - - 0.0
507
1 - - 0.0
608
1 - - 0.0
543
1 - - 0.0
425
1 - - 0.0
579
1 - - 0.0
436
1 - - 0.0
481
1 - - 0.0
439
1 - - 0.0
576
1 - - 0.0
442
1 - - 0.0
502
1 - - 0.0
454
1 - - 0.0
499
1 - - 0.0
587
1 - - 0.0
512
1 - - 0.0
483
1 - - 0.0
529
1 - - 0.0
475
1 - - 0.0
602
1 - - 0.0
594
1 - - 0.0
559
1 - - 0.0
534
1 - - 0.0
462
1 - - 0.0
470
1 - - 0.0
424
1 - - 0.0
612
1 - - 0.0
588
1 - - 0.0
CATH-Gene3D is a Global Biodata Core Resource Learn more...