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CATH Superfamily 3.40.50.12780

ANL, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
N-terminal domain of ligase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Acetyl-coenzyme A synthetase
565
3D
 1ry2A01 - 91.8
3
Long-chain-fatty-acid--CoA ligase FadD
293
3D
 3tsyA01 - 98.0
2
Disco interacting protein 2 homolog B
282 - - 67.4
4
Disco interacting protein 2 homolog A
256 - - 53.1
5
Solute carrier family 27 member 6
254 - - 94.5
6
long-chain-fatty-acid--CoA ligase 6 isoform X2
228 - - 76.9
7
Acyl-coenzyme A synthetase ACSM2A, mitochondrial
210
3D
 3gpcB01 - 92.6
8
Long-chain fatty acid transport protein 4
191 - - 81.9
9
Bifunctional protein Aas
181 - - 28.7
10
Long-chain-fatty-acid--CoA ligase 4 isoform X1
175 - - 74.0
16
Phenylacetate-coenzyme A ligase
140
3D
 4rvoD01 - 93.5
12
Non-ribosomal peptide synthetase
132
3D
 5n9xB01 - 95.4
11
Acetyl-coenzyme A synthetase 2-like, mitochondrial
120
3D
 5gxdA01 - 90.3
13
Long-chain-fatty-acid--AMP ligase FadD32
112
3D
 3t5aA00 - 96.0
14
Nonribosomal peptide synthetase 1
106 - - 95.2
15
D-alanine--D-alanyl carrier protein ligase
106
3D
 4pzpA01 - 43.9
17
Crotonobetaine/carnitine--CoA ligase
101 - - 12.0
18
Fatty acyl CoA synthetase 2
96 - - 90.7
19
Long-chain fatty acid transporter
86 - - 93.9
20
Acetyl-coenzyme A synthetase
84 - - 15.8
21
Long-chain-fatty-acid--CoA ligase ACSBG1 isoform 1
77 - - 33.2
22
Acyl-CoA synthetase
74 - - 65.4
23
Long-chain-fatty-acid--CoA ligase ACSBG1 isoform 1
60 - - 39.4
24
Nonribosomal siderophore peptide synthase SidC
56
3D
 3iteB01 - 91.4
25
luciferin 4-monooxygenase
50 - - 97.5
26
Uncharacterized protein, isoform B
45 - - 47.7
27
AASDH isoform 4
44 - - 68.4
31
Enterobactin synthase component E
43
3D
 4iz6B01 - 11.7
28
Long-chain-fatty-acid--CoA ligase 1
41 - - 83.4
29
Uncharacterized protein, isoform B
36 - - 25.0
30
Acyl-CoA synthetase family member 3
31 - - 83.3
33
Long-chain fatty acid--CoA ligase
30 - - 28.3
32
Acyl--CoA ligase
30 - - 64.0
35
Acetyl-coenzyme A synthetase
28
3D
 3etcB01 - 44.8
34
2-succinylbenzoate--CoA ligase
28 - - 5.8
36
Acetoacetyl-CoA synthetase
26 - - 29.2
37
Acyl-CoA synthetase
25 - - 38.2
38
Ebony protein
24 - - 81.1
39
Peroxisomal-coenzyme A synthetase
23 - - 76.9
40
Acyl-CoA synthetase
22 - - 30.3
41
very long-chain-fatty-acid--CoA ligase bubblegum
22 - - 78.1
44
Short-chain-fatty-acid--CoA ligase
19 - - 3.5
42
Possible fatty-acid-CoA ligase fadD1
19 - - 30.9
43
Acyl-CoA synthetase
19 - - 26.1
45
Acetyl-CoA synthetase, putative
19 - - 75.5
46
L-2-aminoadipate reductase
18 - - 45.4
48
Coenzyme A ligase
17 - - 87.0
47
Acetyl-CoA synthetase, putative
17 - - 8.4
49
Putative acyl-activating enzyme 19
16 - - 88.4
50
Acyl-CoA synthetase
15 - - 10.2
51
Acyl-CoA synthetase
14 - - 4.8
52
YOR093C-like protein
14 - - 72.3
53
Fatty-acid--CoA ligase
13 - - 10.1
57
Possible long-chain acyl-CoA synthase
12 - - 23.3
55
Fatty-acid-CoA ligase FadD22
12 - - 16.0
56
Nonribosomal siderophore peptide synthase SidC
12 - - 65.6
54
Bifunctional fatty acid transporter/acyl-CoA synthetase
FAT1
12 - - 28.5
67
Probable chain-fatty-acid-CoA ligase fadD13
12 - - 0.0
62
Nonribosomal peptide synthetase gliP
11 - - 73.1
59
Coronamic acid synthetase CmaA
11 - - 3.8
60
Acyl-CoA synthetase
11 - - 8.7
61
Acyl-CoA synthetase
11 - - 16.0
58
Acetyl-coenzyme A synthetase
11 - - 65.6
63
Acetyl-coenzyme A synthetase
10 - - 80.6
68
Nonribosomal peptide synthase GliP
10 - - 25.2
70
YOR093C-like protein
10 - - 3.5
64
Probable medium chain fatty-acid-CoA ligase fadD14
10 - - 0.0
69
YOR093C-like protein
10 - - 1.0
65
Fatty-acid-CoA ligase FadD34
10 - - 1.3
66
Probable fatty-acid-CoA ligase fadD6
10 - - 0.0
74
Acyl-CoA synthetase
9 - - 2.1
73
Putative long-chain-fatty-acid--CoA ligase
9 - - 10.9
72
Long-chain-fatty-acid-CoA ligase, putative
9 - - 25.7
71
Long-chain-fatty-acid--ACP ligase MbtM
9 - - 0.9
78
Acyl protein synthase/acyl-CoA reductase RfbN
8 - - 0.3
81
Possible fatty-acid-CoA ligase fadD10
8 - - 1.8
76
Salicyl-AMP ligase / salicyl-S-ArCP synthetase
8 - - 0.0
75
2-succinylbenzoate--CoA ligase
8 - - 36.8
77
Putative long-chain-fatty-acid--CoA ligase
8 - - 9.0
79
Capsule biosynthesis protein CapK
8 - - 4.0
80
Nonribosomal peptide synthase SidE
8 - - 15.0
86
O-succinylbenzoic acid--CoA ligase
7 - - 6.4
85
RfbL protein
7 - - 0.0
87
Acetyl-CoA synthase
7 - - 0.0
89
AMP dependent ligase/synthetase, putative
7 - - 4.2
91
Putative long-chain-fatty-acid--CoA ligase
7 - - 0.0
84
Anthranilate--CoA ligase
7 - - 0.0
88
Possible o-succinylbenzoic acid--CoA ligase menE
7 - - 3.0
90
Long-chain-fatty-acid--CoA ligase FadD15
7 - - 7.2
83
NRPS-like enzyme, putative
7 - - 17.3
82
Fatty-acid-CoA ligase FadD2
7 - - 0.0
95
Acyl-activating enzyme 15
6 - - 24.4
96
Peptide synthetase Nrp
6 - - 0.3
92
Solute carrier family 27 member 4
6 - - 72.1
93
Probable acyl-activating enzyme 18, peroxisomal
6 - - 20.5
94
Acyl-CoA synthetase, putative
6 - - 8.7
100
Nonribosomal peptide synthase Pes1
5 - - 9.4
97
AMP-dependent synthetase and ligase
5 - - 9.0
99
Fatty-acid-CoA ligase FadD9
5 - - 0.0
98
Long-chain-fatty-acid--CoA ligase
5 - - 6.7
104
Ochratoxin A non-ribosomal peptide synthetase
4 - - 0.8
113
Beta-alanine-activating enzyme
4 - - 7.6
117
Acyl-CoA synthetase medium chain family member 5
4 - - 56.2
111
Nonribosomal peptide synthase GliP2
4 - - 0.0
105
Putative long-chain-fatty-acid-CoA ligase
4 - - 9.7
116
solute carrier family 27 member 3 isoform X1
4 - - 42.4
102
ATP-dependent acyl-CoA ligase
4 - - 9.5
106
Putative fatty-acid--CoA ligase fadD11
4 - - 0.0
115
Non-ribosomal peptide synthetase
4 - - 8.8
108
NonRibosomal Peptide Synthetase
4 - - 23.9
109
Probable non-ribosomal peptide synthetase
4 - - 0.8
112
Nonribosomal peptide synthase, putative
4 - - 0.0
103
2-succinylbenzoate--CoA ligase
4 - - 11.9
114
Aspergillus niger contig An11c0010, genomic contig
4 - - 4.0
110
Nonribosomal peptide synthase, putative
4 - - 8.1
101
Acetate-CoA ligase, putative
4 - - 6.9
107
Putative fatty-acid--CoA ligase fadD11
4 - - 0.0
125
PKS-NRPS hybrid synthetase psoA
3 - - 1.0
122
Hydroxamate-type ferrichrome siderophore peptide synthetase
3 - - 35.3
120
Uncharacterized protein
3 - - 0.0
124
Isocyanide synthase-NRPS hybrid crmA
3 - - 0.6
118
Acetyl-coenzyme A synthetase
3 - - 9.6
119
AM-toxin synthetase
3 - - 4.5
123
Nonribosomal peptide synthetase fmqC
3 - - 0.0
121
Acyl-CoA synthetase
3 - - 64.4
127
Nonribosomal peptide synthase, putative
3 - - 0.5
126
Nonribosomal peptide synthetase 8
3 - - 5.8
135
Nonribosomal peptide synthetase, discrete adenylation domain
2 - - 1.3
144
NRPS-like enzyme, putative
AFU_orthologue AFUA_8G01222
2 - - 0.0
140
Acetyl-CoA synthetase
Acetate-CoA ligase AcsA-4
2 - - 38.1
168
Benzoate-coenzyme A ligase, putative
2 - - 35.1
158
Nonribosomal peptide synthase nlsA
2 - - 0.0
159
NRPS-like enzyme, putative
2 - - 0.0
132
8-demethylnovobiocic acid synthase
2 - - 3.2
166
Chromosome 19, whole genome shotgun sequence
2 - - 35.4
156
Nonribosomal peptide synthase nlsA
2 - - 0.0
157
Natural product biosynthesis luciferase-like monooxygenase domain-containing protein
2 - - 9.2
145
NRPS-like enzyme, putative
AFU_orthologue AFUA_8G01222
2 - - 0.0
134
ATP-dependent acyl-CoA ligase
2 - - 0.0
130
Uncharacterized protein
2 - - 6.9
167
Meiotically up-regulated gene 62 protein
2 - - 39.1
161
Putative siderophore synthetase
Eurofung
2 - - 0.0
151
Uncharacterized protein
2 - - 0.0
142
Uncharacterized protein
2 - - 33.2
163
Nonribosomal peptide synthase nlsA
2 - - 0.0
153
Putative pantothenate kinase subunit
2 - - 7.2
146
Uncharacterized protein
2 - - 35.6
133
D-alanine--poly
Phosphoribitol
2 - - 4.9
148
Chromosome 19, whole genome shotgun sequence
2 - - 36.2
149
Nonribosomal peptide synthase Pes1
Eurofung
2 - - 0.0
131
Acyl-CoA synthetase
2 - - 1.3
150
Enniatin synthase
2 - - 1.0
164
Long-chain fatty acid transport protein 1
2 - - 22.5
160
Nonribosomal peptide synthase, putative
JCVI
2 - - 0.0
154
Nonribosomal peptide synthase, putative
JCVI
2 - - 0.0
137
Probable L-prolyl-AMP ligase PigI
2 - - 0.0
136
L-prolyl-AMP Ligase PltF
2 - - 0.0
143
Uncharacterized protein
2 - - 37.6
162
HC-toxin synthetase
2 - - 0.3
152
NRPS-like enzyme, putative
JCVI
2 - - 0.0
139
AMP dependent CoA ligase, putative
2 - - 38.1
141
AMP-binding enzyme, putative
AFU_orthologue AFUA_5G04270
2 - - 0.0
138
Uncharacterized protein
2 - - 0.0
129
2-succinylbenzoate--CoA ligase, chloroplastic/peroxisomal
2 - - 9.0
128
Fatty acid transporter, putative
2 - - 36.4
165
Uncharacterized protein
2 - - 34.7
147
Chromosome 19, whole genome shotgun sequence
2 - - 0.0
155
AMP-binding enzyme, putative
2 - - 0.0
204
Long-chain-fatty-acid--luciferin-component ligase
1 - - 0.0
225
Pantothenate kinase subunit, putative
1 - - 0.0
196
AMP-binding protein
1 - - 0.0
179
Uncharacterized protein
1 - - 0.0
235
Uncharacterized protein
1 - - 0.0
178
Uncharacterized protein
1 - - 0.0
200
Uncharacterized protein
1 - - 0.0
169
Putative acetyl-CoA synethetase
1 - - 0.0
213
Uncharacterized protein
1 - - 0.0
182
Uncharacterized protein
1 - - 0.0
217
Putative long-chain-fatty-acid-CoA ligase
1 - - 0.0
222
Disco interacting protein 2 homolog A
1 - - 0.0
198
Firefly luciferase, putative
1 - - 0.0
199
Uncharacterized protein
1 - - 0.0
176
Uncharacterized protein
1 - - 0.0
232
Uncharacterized protein C56F8.02
1 - - 0.0
211
Uncharacterized protein
1 - - 0.0
185
Uncharacterized protein
1 - - 0.0
193
AMP dependent CoA ligase, putative
1 - - 0.0
230
Uncharacterized protein
1 - - 0.0
205
Uncharacterized protein
1 - - 0.0
224
Uncharacterized protein
1 - - 0.0
220
Uncharacterized protein
1 - - 0.0
234
Uncharacterized protein
1 - - 0.0
171
Putative long-chain fatty-acid-CoA ligase
1 - - 0.0
177
LP07340p
1 - - 0.0
216
Uncharacterized protein
1 - - 0.0
191
Uncharacterized protein
1 - - 0.0
202
Solute carrier family 27 member 2
1 - - 0.0
173
Predicted protein
1 - - 0.0
180
Uncharacterized protein
1 - - 0.0
218
Uncharacterized protein
1 - - 0.0
197
Uncharacterized protein
1 - - 0.0
184
Uncharacterized protein
1 - - 0.0
219
Uncharacterized protein
1 - - 0.0
194
Uncharacterized protein
1 - - 0.0
187
Uncharacterized protein
1 - - 0.0
223
Hydroxamate-type ferrichrome siderophore peptide synthetase
1 - - 0.0
206
Fatty acid transporter protein-like protein
1 - - 0.0
190
Uncharacterized protein
1 - - 0.0
233
Uncharacterized protein
1 - - 0.0
181
Predicted protein
1 - - 0.0
215
Uncharacterized protein
1 - - 0.0
208
Predicted protein
1 - - 0.0
170
SA protein
1 - - 0.0
209
Acyl-CoA synthetase, putative
1 - - 0.0
221
Uncharacterized protein
1 - - 0.0
231
Predicted protein
1 - - 0.0
174
Uncharacterized protein
1 - - 0.0
237
Mutant e4 ebony
1 - - 0.0
183
Acetyl-CoA synthetase
Acetate-CoA ligase AcsA-4
1 - - 0.0
212
Putative long-chain-fatty-acid-CoA ligase
1 - - 0.0
227
Uncharacterized protein
1 - - 0.0
226
Uncharacterized protein
1 - - 0.0
203
Uncharacterized protein
1 - - 0.0
195
Uncharacterized protein
1 - - 0.0
172
Long-chain-fatty-acid--CoA ligase, putative
1 - - 0.0
236
Uncharacterized protein
1 - - 0.0
210
Folliculin-interacting protein 1
1 - - 0.0
214
Uncharacterized protein
1 - - 0.0
188
Uncharacterized protein
1 - - 0.0
189
Uncharacterized protein
1 - - 0.0
201
Uncharacterized protein
1 - - 0.0
229
Mutant e4 ebony
1 - - 0.0
192
Uncharacterized protein
1 - - 0.0
228
Uncharacterized protein
1 - - 0.0
175
Long-chain-fatty-acid-coA ligase protein,putative
1 - - 0.0
239
Uncharacterized protein C162.02c
1 - - 0.0
238
Uncharacterized protein
1 - - 0.0
207
Probable auxin-responsive-like protein
1 - - 0.0
186
MIP16841p
1 - - 0.0
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