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We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
C2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1463
3D
2q3xB00 - 88.5
2
1177
3D
6nytA00 - 93.4
3
986
3D
1v27A00 - 92.7
4
853
3D
4kitB06 - 96.1
5
836
3D
3hn8C02 - 85.7
7
835
3D
5vfgA00 - 89.5
6
830
3D
3fdwB00 - 98.4
8
809
3D
4qj5B04 - 95.1
9
784 - - 86.4
10
759 - - 81.1
11
739
3D
3hn8C01 - 92.7
12
739
3D
4dnlA00 - 84.0
13
698 - - 85.4
14
624 - - 93.5
16
598
3D
5vfeB00 - 90.4
15
590 - - 75.4
17
517 - - 79.0
18
514 - - 90.3
19
492
3D
2ep6A01 - 87.2
20
485 - - 28.6
21
454 - - 70.9
22
444 - - 80.3
23
442
3D
2k3hA00 - 84.8
24
416
3D
3pycA00 - 85.1
25
415
3D
4p42A02 - 93.6
27
393
3D
2d8kA00 - 73.3
26
393 - - 87.9
28
389
3D
3n5aA00 - 84.3
29
381
3D
3jzyA00 - 78.2
30
371
3D
1rlwA00 - 94.9
31
360
3D
2cjtD00 - 79.9
32
359
3D
5lowJ00 - 89.5
33
333 - - 70.6
34
332 - - 90.0
36
325
3D
6bu0C00 - 84.8
35
325 - - 67.1
37
309 - - 74.6
38
308 - - 71.7
41
303
3D
4yknA05 - 85.1
39
302
3D
1w16A00 - 94.4
40
298 - - 84.2
46
288
3D
5dxuA02 - 92.9
42
275 - - 94.2
43
275 - - 81.0
44
265
3D
3l4cB00 - 78.7
45
260 - - 91.3
47
257
3D
2nsqA00 - 76.0
48
256
3D
4kitB12 - 86.8
49
249
3D
1yrkA00 - 90.7
50
245 - - 92.6
51
242
3D
1ugkA00 - 87.1
52
237 - - 54.4
87
236
3D
6c1sA02 - 91.9
53
215
3D
2enpA00 - 85.3
54
209 - - 82.9
61
207
3D
4iqhC00 - 55.7
56
206
3D
2fk9A00 - 89.2
55
205 - - 88.0
59
205
3D
2qz5B00 - 93.3
57
203 - - 53.1
58
202 - - 91.7
60
200 - - 86.3
62
198 - - 87.5
63
190 - - 72.0
64
190 - - 82.2
66
189 - - 89.3
65
189 - - 96.7
68
188 - - 76.4
67
188 - - 84.4
69
182 - - 83.8
70
181 - - 87.3
71
171 - - 71.8
73
170
3D
2yrbA01 - 84.3
72
169 - - 62.2
74
166 - - 73.9
75
163 - - 74.5
76
161 - - 83.8
78
160
3D
2dmgA00 - 74.1
77
160 - - 74.8
84
156
3D
6fjdB00 - 82.5
79
154 - - 75.2
80
151 - - 79.1
82
150 - - 77.3
81
150 - - 50.6
83
148 - - 83.8
85
146 - - 86.2
98
144
3D
2isdB04 - 75.6
86
144 - - 64.6
91
139
3D
4p42A03 - 79.2
88
137 - - 84.2
89
137 - - 52.3
90
135 - - 88.5
92
134
3D
2nq3A00 - 79.7
93
130 - - 95.3
95
129
3D
6eelC00 - 43.2
94
125 - - 74.6
96
124 - - 76.3
97
122 - - 56.8
99
122 - - 88.1
100
121 - - 98.6
101
119 - - 95.1
102
118 - - 92.4
103
116 - - 76.9
105
115
3D
2zkmX04 - 78.1
104
114 - - 72.8
106
113 - - 90.2
107
109 - - 77.4
112
106
3D
6fljA00 - 58.9
111
106
3D
5h4zB00 - 78.4
108
106 - - 90.0
109
105 - - 39.1
110
103 - - 52.2
113
101 - - 96.1
114
100 - - 89.1
115
97 - - 12.2
116
96 - - 70.3
118
94
3D
3l9bA00 - 54.0
117
93 - - 29.7
119
92 - - 86.9
120
91 - - 70.1
121
90 - - 71.7
123
89 - - 46.1
122
89 - - 71.9
133
88
3D
5lj5B12 - 98.2
124
86 - - 83.9
125
83 - - 73.1
127
82 - - 47.0
128
82 - - 81.9
126
82 - - 34.6
130
81 - - 76.0
131
81 - - 95.4
129
81 - - 74.5
132
80 - - 67.6
137
76
3D
1rh8A00 - 75.4
134
76 - - 37.4
135
75 - - 80.7
136
75 - - 71.5
138
73 - - 88.6
139
71 - - 75.1
140
65 - - 85.6
141
65 - - 37.3
143
64 - - 59.1
142
64 - - 72.8
145
62
3D
1wfmA00 - 77.8
144
62 - - 43.1
147
60 - - 72.3
146
60 - - 59.2
148
58 - - 54.5
149
58 - - 95.8
151
57 - - 79.9
150
57 - - 67.6
152
55 - - 77.8
154
54 - - 40.4
155
54 - - 88.0
153
54 - - 66.9
158
53 - - 88.1
159
53 - - 34.8
156
53 - - 79.8
157
53 - - 36.8
161
52 - - 67.5
160
52 - - 71.7
162
51 - - 71.0
164
50 - - 43.4
163
50 - - 73.8
165
49 - - 21.6
166
48 - - 74.7
167
46 - - 77.4
168
45 - - 92.3
169
Npl1
42 - - 75.0
170
41 - - 61.8
173
40 - - 90.0
171
40 - - 69.4
172
40 - - 55.4
174
39 - - 93.4
175
38 - - 39.0
177
37 - - 59.0
176
37 - - 92.8
178
36 - - 25.7
179
36 - - 86.8
181
35 - - 86.3
182
35 - - 87.4
180
35 - - 75.4
183
32 - - 93.5
184
31 - - 73.7
185
31 - - 18.5
188
29 - - 79.0
189
29
3D
4qamB00 - 54.1
186
29 - - 82.1
187
29 - - 71.2
191
27 - - 70.3
192
27 - - 60.8
190
27 - - 56.0
194
26 - - 75.8
195
26 - - 17.0
193
26 - - 72.7
196
25 - - 70.6
216
25
3D
5ug7A00 - 67.1
198
24 - - 75.8
199
24 - - 85.3
200
24 - - 17.0
201
24 - - 77.3
197
24 - - 73.6
202
24 - - 95.2
203
CaLB domain
23 - - 21.1
204
22 - - 20.1
207
21 - - 80.6
210
21 - - 94.8
205
21 - - 62.9
208
21 - - 85.2
209
21 - - 92.6
206
21 - - 22.7
220
20 - - 76.4
217
20 - - 89.4
213
20 - - 45.1
215
20 - - 8.5
214
20 - - 80.9
218
20 - - 77.6
222
20 - - 89.9
211
20 - - 78.5
221
20 - - 87.3
212
20 - - 69.2
219
20 - - 95.6
225
19 - - 10.0
223
19 - - 76.0
226
19 - - 79.5
224
19 - - 4.9
230
18 - - 74.2
227
18 - - 4.1
229
18 - - 3.0
231
18 - - 92.0
228
18 - - 21.8
237
17 - - 96.1
233
17 - - 14.0
235
17 - - 24.4
234
17 - - 19.5
232
17 - - 0.0
236
17 - - 18.5
240
16 - - 27.5
238
16 - - 74.3
239
16 - - 32.7
243
15 - - 91.3
242
CaLB domain
15 - - 30.3
244
15 - - 60.5
241
15 - - 83.3
245
14 - - 14.6
247
14 - - 0.0
246
14 - - 41.8
248
14 - - 20.2
263
14
3D
3fbkB00 - 90.7
256
13 - - 83.3
252
13 - - 51.7
251
13 - - 2.9
254
13 - - 12.2
258
13 - - 7.3
249
13 - - 75.7
250
13 - - 10.3
253
13 - - 12.0
255
13 - - 71.4
257
13 - - 45.5
264
12 - - 84.9
261
12 - - 50.6
259
PIK-A
12 - - 18.4
262
12 - - 31.4
265
12 - - 2.8
260
12 - - 63.9
268
11 - - 15.1
270
11 - - 5.8
273
11 - - 97.4
269
11 - - 2.9
266
11 - - 65.1
267
11 - - 11.3
272
11 - - 76.6
365
11
3D
5lj5B06 - 7.1
271
11 - - 4.6
286
10 - - 20.8
282
10 - - 14.6
275
10 - - 49.7
289
10 - - 89.0
281
10 - - 70.3
284
10 - - 8.0
288
10 - - 75.5
291
10 - - 76.1
277
10 - - 65.5
290
DUF3451
10 - - 41.3
276
10 - - 9.8
280
10 - - 9.5
283
10 - - 8.9
279
10 - - 0.0
285
10 - - 50.3
274
10 - - 81.3
278
10 - - 4.9
287
10 - - 66.5
300
9 - - 69.0
296
9 - - 22.4
292
9 - - 44.7
303
9 - - 18.0
299
9 - - 12.8
294
9 - - 78.9
298
9 - - 2.7
293
9 - - 74.7
302
9 - - 13.9
295
9 - - 71.4
301
9 - - 75.5
304
9 - - 22.9
297
9 - - 8.7
315
8 - - 13.5
313
8 - - 46.4
310
8 - - 11.3
305
8 - - 1.7
317
8 - - 8.1
323
8 - - 70.8
320
8 - - 15.5
307
8 - - 77.1
325
8 - - 23.5
319
8 - - 23.7
306
8 - - 61.0
321
8 - - 17.0
324
8 - - 11.8
312
8 - - 33.3
316
8 - - 15.6
309
8 - - 85.9
322
8 - - 38.9
326
8 - - 83.9
318
8 - - 15.2
314
8 - - 70.8
311
8 - - 1.0
308
8 - - 36.4
335
7 - - 2.2
330
7 - - 12.2
327
7 - - 5.7
333
PKN
7 - - 21.2
347
7 - - 35.5
340
7 - - 10.9
343
7 - - 4.5
337
7 - - 6.0
345
7 - - 5.7
339
7 - - 6.1
344
7 - - 11.2
348
7 - - 88.5
328
7 - - 90.3
336
7 - - 3.4
332
7 - - 14.9
341
7 - - 3.7
334
7 - - 4.1
338
7 - - 1.1
346
7 - - 83.5
342
7 - - 1.6
331
7 - - 10.3
349
7 - - 95.1
329
7 - - 40.4
351
6 - - 84.7
358
6 - - 53.6
366
6 - - 5.3
354
6 - - 4.9
362
6 - - 16.4
359
6 - - 52.8
352
6 - - 85.0
364
6 - - 16.1
368
6 - - 48.3
356
6 - - 15.0
361
6 - - 78.8
360
6 - - 0.7
357
6 - - 16.8
363
6 - - 43.1
355
6 - - 14.2
353
6 - - 46.5
350
6 - - 33.9
367
6 - - 14.8
398
5 - - 21.9
381
5 - - 7.9
404
5 - - 86.4
394
5 - - 94.3
377
5 - - 28.4
388
5 - - 0.0
401
5 - - 76.5
391
5 - - 0.0
384
5 - - 73.7
369
5 - - 0.9
399
5 - - 68.4
375
5 - - 72.8
389
5 - - 7.2
373
5 - - 17.5
370
5 - - 19.2
382
5 - - 13.4
386
5 - - 75.2
402
5 - - 69.4
392
5 - - 74.1
396
5 - - 12.2
387
5 - - 9.6
378
5 - - 40.4
374
5 - - 0.0
371
5 - - 52.9
397
5 - - 8.1
379
5 - - 17.0
395
5 - - 92.5
405
5 - - 68.6
385
5 - - 83.2
403
5 - - 42.4
393
5 - - 48.1
390
5 - - 12.2
400
5 - - 67.3
383
5 - - 41.5
380
5 - - 11.7
372
5 - - 20.2
376
5 - - 29.4
408
4 - - 48.9
411
4 - - 10.0
422
4 - - 10.0
414
4 - - 39.2
418
4 - - 13.1
424
4 - - 64.3
409
4 - - 70.1
416
4 - - 38.8
412
4 - - 26.2
421
4 - - 12.5
406
4 - - 3.0
419
4 - - 7.8
425
4 - - 89.9
407
4 - - 7.5
417
4 - - 11.4
420
4 - - 17.5
423
4 - - 73.9
410
4 - - 17.0
413
4 - - 41.9
415
4 - - 45.4
467
3 - - 63.3
450
3 - - 10.3
453
3 - - 0.0
429
3 - - 15.2
449
3 - - 0.0
442
3 - - 0.8
455
3 - - 0.0
446
3 - - 15.0
431
3 - - 69.8
426
3 - - 7.9
438
3 - - 37.1
434
3 - - 6.9
432
3 - - 72.9
436
3 - - 4.6
428
3 - - 0.7
441
3 - - 41.9
448
CaLB domain
3 - - 4.2
444
3 - - 0.0
465
3 - - 46.6
463
3 - - 46.0
439
3 - - 15.8
457
3 - - 1.0
460
3 - - 4.5
461
3 - - 4.2
470
3 - - 63.3
456
3 - - 0.0
468
3 - - 61.2
452
3 - - 12.6
464
3 - - 40.7
445
3 - - 3.7
437
3 - - 34.4
459
3 - - 0.8
443
3 - - 6.1
440
3 - - 71.1
447
3 - - 0.0
433
3 - - 4.5
469
3 - - 67.3
427
3 - - 23.5
430
3 - - 34.4
454
3 - - 0.0
462
3 - - 8.2
466
3 - - 29.9
458
3 - - 0.0
435
3 - - 16.9
451
3 - - 0.0
583
2 - - 40.5
504
2 - - 0.0
480
2 - - 6.6
483
2 - - 0.0
580
2 - - 31.6
508
2 - - 7.4
553
2 - - 43.1
529
2 - - 0.0
572
2 - - 0.0
476
2 - - 10.6
567
2 - - 0.0
472
2 - - 0.0
576
2 - - 0.0
550
2 - - 33.6
593
2 - - 40.5
490
2 - - 5.0
501
2 - - 0.0
493
2 - - 10.0
590
MKS
2 - - 41.9
549
2 - - 11.4
546
2 - - 1.8
511
2 - - 2.2
542
2 - - 0.0
555
2 - - 3.2
485
2 - - 21.7
531
2 - - 3.2
585
2 - - 12.6
534
2 - - 3.8
522
2 - - 26.8
579
2 - - 30.0
495
2 - - 0.8
526
2 - - 38.2
479
2 - - 15.1
538
2 - - 0.0
595
2 - - 46.1
518
2 - - 20.5
514
2 - - 21.2
536
2 - - 0.0
528
2 - - 17.9
532
2 - - 0.0
524
2 - - 39.8
512
2 - - 14.0
541
2 - - 0.0
509
2 - - 6.3
516
2 - - 15.5
544
2 - - 0.0
565
2 - - 3.7
548
2 - - 0.0
521
2 - - 25.9
571
2 - - 0.0
471
2 - - 4.8
497
2 - - 0.0
506
2 - - 10.6
587
2 - - 42.6
519
2 - - 25.3
502
2 - - 11.4
487
2 - - 34.4
578
2 - - 20.5
557
2 - - 0.0
474
2 - - 10.0
560
2 - - 2.2
478
2 - - 33.8
563
2 - - 0.0
574
2 - - 0.0
539
2 - - 0.0
592
2 - - 41.2
496
2 - - 0.0
492
2 - - 0.0
525
2 - - 43.4
561
2 - - 0.0
564
2 - - 0.9
552
2 - - 38.8
573
2 - - 15.4
545
2 - - 3.0
556
2 - - 0.0
570
2 - - 2.8
473
2 - - 0.0
568
2 - - 0.0
486
2 - - 14.5
582
2 - - 37.9
586
2 - - 41.5
507
2 - - 3.6
482
2 - - 0.0
589
2 - - 44.9
517
2 - - 24.1
489
2 - - 44.7
523
2 - - 0.0
559
2 - - 5.3
537
2 - - 4.0
520
2 - - 24.5
475
2 - - 0.8
540
2 - - 12.2
575
2 - - 7.3
543
2 - - 9.4
499
2 - - 0.9
505
2 - - 0.0
547
2 - - 7.4
513
2 - - 22.5
510
2 - - 14.8
527
2 - - 39.4
530
2 - - 1.3
533
2 - - 10.0
569
2 - - 0.8
566
2 - - 5.7
577
2 - - 0.0
558
CaLB domain
2 - - 0.0
562
2 - - 0.0
554
2 - - 14.2
477
2 - - 10.0
591
2 - - 43.3
484
2 - - 29.7
500
2 - - 0.9
588
2 - - 39.5
503
2 - - 1.0
584
2 - - 42.0
491
2 - - 0.0
488
2 - - 40.1
581
2 - - 36.4
494
2 - - 2.3
535
2 - - 2.5
594
2 - - 44.0
481
2 - - 12.5
498
2 - - 0.0
551
2 - - 39.0
515
2 - - 25.6
648
1 - - 0.0
795
1 - - 0.0
738
1 - - 0.0
820
1 - - 0.0
726
1 - - 0.0
665
1 - - 0.0
779
1 - - 0.0
722
1 - - 0.0
644
1 - - 0.0
734
1 - - 0.0
823
1 - - 0.0
714
1 - - 0.0
817
1 - - 0.0
621
1 - - 0.0
718
1 - - 0.0
755
1 - - 0.0
624
1 - - 0.0
742
1 - - 0.0
632
1 - - 0.0
711
1 - - 0.0
628
1 - - 0.0
636
1 - - 0.0
746
1 - - 0.0
785
1 - - 0.0
616
1 - - 0.0
609
1 - - 0.0
731
1 - - 0.0
641
1 - - 0.0
612
1 - - 0.0
602
1 - - 0.0
619
1 - - 0.0
687
1 - - 0.0
606
1 - - 0.0
639
1 - - 0.0
825
1 - - 0.0
674
1 - - 0.0
749
1 - - 0.0
790
1 - - 0.0
663
1 - - 0.0
701
1 - - 0.0
660
1 - - 0.0
657
1 - - 0.0
678
1 - - 0.0
793
1 - - 0.0
708
1 - - 0.0
780
1 - - 0.0
807
1 - - 0.0
671
1 - - 0.0
783
1 - - 0.0
704
1 - - 0.0
750
1 - - 0.0
776
1 - - 0.0
767
1 - - 0.0
772
1 - - 0.0
729
1 - - 0.0
753
1 - - 0.0
697
1 - - 0.0
702
1 - - 0.0
803
1 - - 0.0
800
1 - - 0.0
719
1 - - 0.0
787
1 - - 0.0
706
1 - - 0.0
739
1 - - 0.0
774
1 - - 0.0
649
1 - - 0.0
690
1 - - 0.0
763
1 - - 0.0
601
1 - - 0.0
760
1 - - 0.0
757
1 - - 0.0
693
1 - - 0.0
778
1 - - 0.0
608
1 - - 0.0
680
1 - - 0.0
815
1 - - 0.0
771
1 - - 0.0
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810
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610
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1 - - 0.0
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