The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Amino acid/polyamine transporter I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Y+L amino acid transporter 1 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Amino acid transmembrane transporter activity GO:0015171
Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
5 A0A0B4KHK8 (/ISS) Q01650 (/ISS) Q63016 (/ISS) Q9V9Y0 (/ISS) Q9VB75 (/ISS)
Amino acid transmembrane transporter activity GO:0015171
Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
5 Q92536 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q9Y1A7 (/TAS)
L-leucine transmembrane transporter activity GO:0015190
Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid.
3 Q63016 (/ISS) Q7YQK4 (/ISS) Q9Z127 (/ISS)
L-tryptophan transmembrane transporter activity GO:0015196
Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid.
3 Q63016 (/ISS) Q7YQK4 (/ISS) Q9Z127 (/ISS)
L-leucine transmembrane transporter activity GO:0015190
Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid.
2 Q01650 (/IDA) Q9TU26 (/IDA)
L-tryptophan transmembrane transporter activity GO:0015196
Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid.
2 Q01650 (/IDA) Q9TU26 (/IDA)
Peptide antigen binding GO:0042605
Interacting selectively and non-covalently with an antigen peptide.
2 Q01650 (/ISS) Q63016 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q01650 (/IPI)
Amino acid transmembrane transporter activity GO:0015171
Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
1 Q7YQK4 (/IDA)
Basic amino acid transmembrane transporter activity GO:0015174
Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7.
1 Q9Z1K8 (/IMP)
L-amino acid transmembrane transporter activity GO:0015179
Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids.
1 Q9Z127 (/IDA)
L-phenylalanine transmembrane transporter activity GO:0015192
Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid.
1 Q9TU26 (/IDA)
Peptide antigen binding GO:0042605
Interacting selectively and non-covalently with an antigen peptide.
1 Q7YQK4 (/IPI)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Amino acid transport GO:0006865
The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
9 Q92536 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS) Q9Y1A7 (/TAS)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
9 Q01650 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS)
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
8 Q92536 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS)
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
8 Q92536 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS)
Amino acid transmembrane transport GO:0003333
The process in which an amino acid is transported across a membrane.
3 A0A0B4KHK8 (/ISS) Q9V9Y0 (/ISS) Q9VB75 (/ISS)
L-tryptophan transmembrane transport GO:1904556
The directed movement of L-tryptophan across a membrane.
3 Q63016 (/ISS) Q7YQK4 (/ISS) Q9Z127 (/ISS)
Amino acid transmembrane transport GO:0003333
The process in which an amino acid is transported across a membrane.
2 O17395 (/IDA) Q19834 (/IDA)
Microglia development GO:0014005
The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
2 F1R8V8 (/IMP) Q2YDQ4 (/IMP)
Neutral amino acid transport GO:0015804
The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q01650 (/ISS) Q63016 (/ISS)
L-leucine import across plasma membrane GO:1903801
The directed movement of L-leucine from outside of a cell, across the plasma membrane and into the cytosol.
2 Q9VKC2 (/IMP) Q9Y1A7 (/IMP)
Regulation of arginine metabolic process GO:0000821
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
1 Q9Z1K8 (/IMP)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 Q9VB75 (/IMP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 Q9Y1A7 (/TAS)
Chemosensory behavior GO:0007635
Behavior that is dependent upon the sensation of chemicals.
1 Q9VB75 (/IMP)
Male courtship behavior GO:0008049
The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster.
1 Q9VB75 (/IMP)
Toll signaling pathway GO:0008063
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9Y1A7 (/TAS)
Glutamate secretion GO:0014047
The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system.
1 Q9VB75 (/IMP)
Neutral amino acid transport GO:0015804
The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q7YQK4 (/IDA)
Neutral amino acid transport GO:0015804
The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q96QB2 (/IMP)
L-amino acid transport GO:0015807
The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9Z127 (/IDA)
Leucine transport GO:0015820
The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9TU26 (/IDA)
Phenylalanine transport GO:0015823
The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9TU26 (/IDA)
Tryptophan transport GO:0015827
The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9TU26 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 Q9VB75 (/IMP)
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
1 Q9VKC2 (/IMP)
L-alpha-amino acid transmembrane transport GO:1902475
The directed movement of L-alpha-amino acid across a membrane.
1 Q01650 (/TAS)
L-tryptophan transmembrane transport GO:1904556
The directed movement of L-tryptophan across a membrane.
1 Q01650 (/IDA)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
11 A0A024R719 (/IDA) A0A024R719 (/IDA) A0A024R719 (/IDA) A0A024R719 (/IDA) O17395 (/IDA) Q01650 (/IDA) Q19834 (/IDA) Q92536 (/IDA) Q92536 (/IDA) Q92536 (/IDA)
(1 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 Q01650 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
9 A0A024R719 (/IDA) A0A024R719 (/IDA) A0A024R719 (/IDA) A0A024R719 (/IDA) Q01650 (/IDA) Q92536 (/IDA) Q92536 (/IDA) Q92536 (/IDA) Q92536 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
8 Q92536 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q92536 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS) Q9UM01 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q63016 (/ISS) Q7YQK4 (/ISS) Q9Z127 (/ISS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 Q63016 (/ISS) Q7YQK4 (/ISS) Q9Z127 (/ISS)
Amino acid transport complex GO:1990184
A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane.
3 Q63016 (/ISS) Q7YQK4 (/ISS) Q9Z127 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8BGK6 (/ISO) Q9Z127 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 Q8BGK6 (/ISO) Q9Z127 (/ISO)
Amino acid transport complex GO:1990184
A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane.
2 O17395 (/IPI) Q19834 (/IPI)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9Y1A7 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q01650 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9Z127 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9Y1A7 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q01650 (/HDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q01650 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q7YQK4 (/TAS)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
1 Q9VB75 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q01650 (/HDA)
Amino acid transport complex GO:1990184
A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane.
1 Q01650 (/IDA)
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