The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Amino acid/polyamine transporter I
".
FunFam 27: cystine/glutamate transporter isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | Q9UPY5 (/IPI) Q9UPY5 (/IPI) Q9UPY5 (/IPI) |
Cystine:glutamate antiporter activity GO:0015327
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out).
|
3 | Q9UPY5 (/TAS) Q9UPY5 (/TAS) Q9UPY5 (/TAS) |
There are 39 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Amino acid transport GO:0006865
The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
3 | Q9UPY5 (/TAS) Q9UPY5 (/TAS) Q9UPY5 (/TAS) |
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
|
3 | Q9UPY5 (/IDA) Q9UPY5 (/IDA) Q9UPY5 (/IDA) |
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
|
3 | Q9UPY5 (/TAS) Q9UPY5 (/TAS) Q9UPY5 (/TAS) |
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
|
2 | Q9WTR6 (/ISO) Q9WTR6 (/ISO) |
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Ventricular system development GO:0021591
The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Striatum development GO:0021756
The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Adult behavior GO:0030534
Behavior in a fully developed and mature organism.
|
2 | Q9WTR6 (/IDA) Q9WTR6 (/IDA) |
Regulation of neutrophil apoptotic process GO:0033029
Any process that modulates the frequency, rate, or extent of neutrophil apoptotic process.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Glutathione transmembrane transport GO:0034775
A process in which glutathione is transported across a membrane.
|
2 | Q9WTR6 (/IDA) Q9WTR6 (/IDA) |
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Regulation of melanin biosynthetic process GO:0048021
Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Lung alveolus development GO:0048286
The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Regulation of synapse organization GO:0050807
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Regulation of protein transport GO:0051223
Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Response to redox state GO:0051775
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Limb development GO:0060173
The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Platelet aggregation GO:0070527
The adhesion of one platelet to one or more other platelets via adhesion molecules.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Organic substance transport GO:0071702
The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Glutamate homeostasis GO:0090461
Any process involved in the maintenance of an internal steady state of glutamate within an organism or cell.
|
2 | Q9WTR6 (/IGI) Q9WTR6 (/IGI) |
Glutamate homeostasis GO:0090461
Any process involved in the maintenance of an internal steady state of glutamate within an organism or cell.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
L-glutamate import across plasma membrane GO:0098712
The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Dipeptide import across plasma membrane GO:0140206
The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Regulation of cellular response to oxidative stress GO:1900407
Any process that modulates the frequency, rate or extent of cellular response to oxidative stress.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Regulation of cysteine metabolic process GO:1901494
Any process that modulates the frequency, rate or extent of cysteine metabolic process.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Negative regulation of oxidative stress-induced neuron death GO:1903204
Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death.
|
2 | Q9WTR6 (/IDA) Q9WTR6 (/IDA) |
Negative regulation of oxidative stress-induced neuron death GO:1903204
Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Regulation of glutathione biosynthetic process GO:1903786
Any process that modulates the frequency, rate or extent of glutathione biosynthetic process.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Regulation of AMPA glutamate receptor clustering GO:1904717
Any process that modulates the frequency, rate or extent of AMPA glutamate receptor clustering.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Regulation of glutamate metabolic process GO:2000211
Any process that modulates the frequency, rate or extent of glutamate metabolic process.
|
2 | Q9WTR6 (/IMP) Q9WTR6 (/IMP) |
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | D4ADU2 (/IEP) |
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
1 | D4ADU2 (/IEP) |
Response to nicotine GO:0035094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
|
1 | D4ADU2 (/IEP) |
Lens fiber cell differentiation GO:0070306
The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities.
|
1 | D4ADU2 (/IEP) |
There are 15 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q9UPY5 (/TAS) Q9UPY5 (/TAS) Q9UPY5 (/TAS) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
3 | Q9UPY5 (/IDA) Q9UPY5 (/IDA) Q9UPY5 (/IDA) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | Q9UPY5 (/TAS) Q9UPY5 (/TAS) Q9UPY5 (/TAS) |
Rough endoplasmic reticulum GO:0005791
The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
|
2 | Q9WTR6 (/ISO) Q9WTR6 (/ISO) |
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
|
2 | Q9WTR6 (/ISO) Q9WTR6 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q9WTR6 (/ISO) Q9WTR6 (/ISO) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | Q9WTR6 (/ISO) Q9WTR6 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | Q9WTR6 (/IDA) Q9WTR6 (/IDA) |
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
|
2 | Q9WTR6 (/IDA) Q9WTR6 (/IDA) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
2 | Q9WTR6 (/ISO) Q9WTR6 (/ISO) |
Astrocyte projection GO:0097449
A prolongation or process extending from the soma of an astrocyte and wrapping around neurons.
|
2 | Q9WTR6 (/IDA) Q9WTR6 (/IDA) |
Rough endoplasmic reticulum GO:0005791
The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
|
1 | D4ADU2 (/IDA) |
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
|
1 | D4ADU2 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | D4ADU2 (/IDA) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | D4ADU2 (/IDA) |