The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Amino acid/polyamine transporter I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Putative solute carrier family 12 member 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Potassium:chloride symporter activity GO:0015379
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in).
10 Q63633 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9UHW9 (/IDA) Q9UHW9 (/IDA) Q9UHW9 (/IDA) Q9UHW9 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
7 Q91V14 (/ISO) Q91V14 (/ISO) Q924N4 (/ISO) Q9JIS8 (/ISO) Q9JIS8 (/ISO) Q9WVL3 (/ISO) Q9WVL3 (/ISO)
Chloride transmembrane transporter activity GO:0015108
Enables the transfer of chloride ions from one side of a membrane to the other.
5 Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA)
Potassium:chloride symporter activity GO:0015379
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in).
3 Q91V14 (/ISO) Q91V14 (/ISO) Q924N4 (/ISO)
Potassium:chloride symporter activity GO:0015379
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in).
3 Q5RK27 (/TAS) Q9UP95 (/TAS) Q9Y666 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q63633 (/IPI) Q924N4 (/IPI)
Ammonium transmembrane transporter activity GO:0008519
Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals.
2 Q91V14 (/ISO) Q91V14 (/ISO)
Chloride transmembrane transporter activity GO:0015108
Enables the transfer of chloride ions from one side of a membrane to the other.
2 Q91V14 (/ISO) Q91V14 (/ISO)
Potassium:chloride symporter activity GO:0015379
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in).
2 Q91V14 (/IMP) Q91V14 (/IMP)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 Q9UP95 (/IPI) Q9Y666 (/IPI)
Ammonium transmembrane transporter activity GO:0008519
Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals.
1 Q63633 (/IDA)
Potassium ion transmembrane transporter activity GO:0015079
Enables the transfer of potassium ions (K+) from one side of a membrane to the other.
1 Q924N4 (/ISO)
Potassium:chloride symporter activity GO:0015379
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in).
1 Q924N4 (/ISS)

There are 37 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
11 Q9H2X9 (/TAS) Q9H2X9 (/TAS) Q9H2X9 (/TAS) Q9H2X9 (/TAS) Q9H2X9 (/TAS) Q9UHW9 (/TAS) Q9UHW9 (/TAS) Q9UHW9 (/TAS) Q9UHW9 (/TAS) Q9UP95 (/TAS)
(1 more)
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
9 Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9UHW9 (/IDA) Q9UHW9 (/IDA) Q9UHW9 (/IDA) Q9UHW9 (/IDA)
Dendritic spine development GO:0060996
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
6 Q63633 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA)
Cellular ion homeostasis GO:0006873
Any process involved in the maintenance of an internal steady state of ions at the level of a cell.
5 Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA)
Hypotonic response GO:0006971
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.
5 Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA)
Cellular chloride ion homeostasis GO:0030644
Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell.
5 Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
4 Q9UHW9 (/NAS) Q9UHW9 (/NAS) Q9UHW9 (/NAS) Q9UHW9 (/NAS)
Cellular hypotonic salinity response GO:0071477
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
4 Q9UHW9 (/IDA) Q9UHW9 (/IDA) Q9UHW9 (/IDA) Q9UHW9 (/IDA)
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q91V14 (/ISO) Q91V14 (/ISO) Q924N4 (/ISO)
Posterior lateral line neuromast development GO:0048919
The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals.
3 A0A2R8RX62 (/IGI) E9QC71 (/IGI) F1R5T1 (/IGI)
Posterior lateral line neuromast development GO:0048919
The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals.
3 A0A2R8RX62 (/IMP) E9QC71 (/IMP) F1R5T1 (/IMP)
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
3 A0A2R8RX62 (/IMP) E9QC71 (/IMP) F1R5T1 (/IMP)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q91V14 (/ISO) Q91V14 (/ISO)
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q91V14 (/IMP) Q91V14 (/IMP)
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q91V14 (/ISO) Q91V14 (/ISO)
Cellular ion homeostasis GO:0006873
Any process involved in the maintenance of an internal steady state of ions at the level of a cell.
2 Q91V14 (/ISO) Q91V14 (/ISO)
Cell volume homeostasis GO:0006884
Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell.
2 Q9WVL3 (/ISO) Q9WVL3 (/ISO)
Hypotonic response GO:0006971
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.
2 Q91V14 (/ISO) Q91V14 (/ISO)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2 Q91V14 (/IMP) Q91V14 (/IMP)
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
2 Q91V14 (/IMP) Q91V14 (/IMP)
Ammonium transport GO:0015696
The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals.
2 Q91V14 (/ISO) Q91V14 (/ISO)
Cellular chloride ion homeostasis GO:0030644
Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell.
2 Q91V14 (/ISO) Q91V14 (/ISO)
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
2 Q91V14 (/IMP) Q91V14 (/IMP)
Thermosensory behavior GO:0040040
Behavior that is dependent upon the sensation of temperature.
2 Q91V14 (/IMP) Q91V14 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 Q91V14 (/IMP) Q91V14 (/IMP)
Intracellular pH reduction GO:0051452
Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.
2 Q91V14 (/ISO) Q91V14 (/ISO)
Dendritic spine development GO:0060996
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
2 Q91V14 (/ISO) Q91V14 (/ISO)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q63633 (/IDA)
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q63633 (/IDA)
Cell volume homeostasis GO:0006884
Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell.
1 Q5RK27 (/IMP)
Cell volume homeostasis GO:0006884
Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell.
1 Q9UP95 (/TAS)
Ammonium transport GO:0015696
The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals.
1 Q63633 (/IDA)
Intracellular pH reduction GO:0051452
Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.
1 Q63633 (/IDA)
Cellular hypotonic response GO:0071476
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.
1 Q924N4 (/ISO)
Cellular hypotonic salinity response GO:0071477
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 Q924N4 (/ISO)
Cellular hypotonic salinity response GO:0071477
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 Q924N4 (/ISS)
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
1 Q924N4 (/ISO)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
11 Q9H2X9 (/TAS) Q9H2X9 (/TAS) Q9H2X9 (/TAS) Q9H2X9 (/TAS) Q9H2X9 (/TAS) Q9UHW9 (/TAS) Q9UHW9 (/TAS) Q9UHW9 (/TAS) Q9UHW9 (/TAS) Q9UP95 (/TAS)
(1 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA) Q9H2X9 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 Q9UHW9 (/NAS) Q9UHW9 (/NAS) Q9UHW9 (/NAS) Q9UHW9 (/NAS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
4 Q9UHW9 (/ISS) Q9UHW9 (/ISS) Q9UHW9 (/ISS) Q9UHW9 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q63633 (/IDA) Q91V14 (/IDA) Q91V14 (/IDA)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
2 B4DF30 (/HDA) Q9UP95 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q91V14 (/ISO) Q91V14 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9UP95 (/TAS) Q9Y666 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q91V14 (/ISO) Q91V14 (/ISO)
Dendrite membrane GO:0032590
The portion of the plasma membrane surrounding a dendrite.
2 Q91V14 (/ISO) Q91V14 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 Q9WVL3 (/ISO) Q9WVL3 (/ISO)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
2 Q91V14 (/ISO) Q91V14 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9UP95 (/TAS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q924N4 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q924N4 (/IDA)
Dendrite membrane GO:0032590
The portion of the plasma membrane surrounding a dendrite.
1 Q63633 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9Y666 (/IDA)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
1 Q63633 (/IDA)
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