The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Amino acid/polyamine transporter I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: Amino acid permease

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Amino acid transmembrane transporter activity GO:0015171
Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
13 A0A1D8PK89 (/IDA) A0A1D8PMB1 (/IDA) P25376 (/IDA) P25376 (/IDA) P38084 (/IDA) P38084 (/IDA) P38085 (/IDA) P38085 (/IDA) P41815 (/IDA) P41815 (/IDA)
(3 more)
L-phenylalanine transmembrane transporter activity GO:0015192
Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid.
6 P19145 (/IMP) P19145 (/IMP) P25376 (/IMP) P25376 (/IMP) P38084 (/IMP) P38084 (/IMP)
L-proline transmembrane transporter activity GO:0015193
Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid.
6 P19145 (/IGI) P19145 (/IGI) P25376 (/IGI) P25376 (/IGI) P48813 (/IGI) P48813 (/IGI)
Amino acid transmembrane transporter activity GO:0015171
Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
3 B5BP45 (/ISM) Q9P5N2 (/ISM) Q9P5N4 (/ISM)
Beta-alanine transmembrane transporter activity GO:0001761
Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid.
2 P19145 (/IMP) P19145 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P38084 (/IPI) P38084 (/IPI)
Amino acid transmembrane transporter activity GO:0015171
Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
2 P19145 (/IMP) P19145 (/IMP)
Polyamine transmembrane transporter activity GO:0015203
Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other.
2 P19145 (/IMP) P19145 (/IMP)
Low-affinity tryptophan transmembrane transporter activity GO:0022893
Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.
2 P38085 (/IGI) P38085 (/IGI)
Arginine transmembrane transporter activity GO:0015181
Enables the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane.
1 Q9URZ4 (/IGI)
Arginine transmembrane transporter activity GO:0015181
Enables the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane.
1 Q9URZ4 (/IMP)
L-lysine transmembrane transporter activity GO:0015189
Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid.
1 Q9URZ4 (/IMP)
L-proline transmembrane transporter activity GO:0015193
Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid.
1 Q9P768 (/IC)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Amino acid transport GO:0006865
The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
11 P25376 (/IDA) P25376 (/IDA) P38084 (/IDA) P38084 (/IDA) P38085 (/IDA) P38085 (/IDA) P41815 (/IDA) P41815 (/IDA) P41815 (/IDA) P48813 (/IDA)
(1 more)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
11 P25376 (/IDA) P25376 (/IDA) P38084 (/IDA) P38084 (/IDA) P38085 (/IDA) P38085 (/IDA) P41815 (/IDA) P41815 (/IDA) P41815 (/IDA) P48813 (/IDA)
(1 more)
Amino acid transmembrane transport GO:0003333
The process in which an amino acid is transported across a membrane.
3 B5BP45 (/ISM) Q9P5N2 (/ISM) Q9P5N4 (/ISM)
Amino acid transmembrane transport GO:0003333
The process in which an amino acid is transported across a membrane.
2 A0A1D8PK89 (/IMP) A0A1D8PMB1 (/IMP)
Amino acid transport GO:0006865
The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P19145 (/IMP) P19145 (/IMP)
Tryptophan transport GO:0015827
The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P38085 (/IGI) P38085 (/IGI)
Tyrosine transport GO:0015828
The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P38085 (/IMP) P38085 (/IMP)
Polyamine transport GO:0015846
The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P19145 (/IMP) P19145 (/IMP)
Leucine import across plasma membrane GO:0098713
The directed movement of leucine from outside of a cell, across the plasma membrane and into the cytosol.
2 P38084 (/IMP) P38084 (/IMP)
Nitrogen utilization GO:0019740
A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism.
1 Q9P768 (/IMP)
L-arginine import across plasma membrane GO:0097638
The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol.
1 Q9URZ4 (/IMP)
L-lysine import across plasma membrane GO:0097639
The directed movement of L-lysine from outside of a cell, across the plasma membrane and into the cytosol.
1 Q9URZ4 (/IMP)
Proline import across plasma membrane GO:1905647
The directed movement of proline from outside of a cell into the cytoplasmic compartment.
1 Q9P768 (/NAS)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
13 P19145 (/HDA) P19145 (/HDA) P25376 (/HDA) P25376 (/HDA) P38084 (/HDA) P38084 (/HDA) P38085 (/HDA) P38085 (/HDA) P41815 (/HDA) P41815 (/HDA)
(3 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 P19145 (/IDA) P19145 (/IDA) P25376 (/IDA) P25376 (/IDA) P38084 (/IDA) P38084 (/IDA) P38085 (/IDA) P38085 (/IDA) Q9P5N2 (/IDA) Q9URZ4 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 P41815 (/HDA) P41815 (/HDA) P41815 (/HDA) P48813 (/HDA) P48813 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P41815 (/ISS) P41815 (/ISS) P41815 (/ISS) P48813 (/ISS) P48813 (/ISS)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
4 P38085 (/HDA) P38085 (/HDA) P48813 (/HDA) P48813 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
3 Q9P5N2 (/HDA) Q9P5N4 (/HDA) Q9P768 (/HDA)
Fungal-type vacuole lumen GO:0000328
The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae.
2 P19145 (/IDA) P19145 (/IDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
2 P19145 (/IDA) P19145 (/IDA)
Multivesicular body GO:0005771
A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
2 P19145 (/IMP) P19145 (/IMP)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P19145 (/IDA) P19145 (/IDA)
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
2 P48813 (/HDA) P48813 (/HDA)
COPII-coated ER to Golgi transport vesicle GO:0030134
A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport).
2 P19145 (/IDA) P19145 (/IDA)
Plasma membrane of cell tip GO:0031520
The portion of the plasma membrane surrounding the cell tip.
2 Q9P5N2 (/IDA) Q9URZ4 (/IDA)
Cell tip GO:0051286
The region at the end of the longest axis of a cylindrical or elongated cell.
2 Q9P5N2 (/HDA) Q9P768 (/HDA)
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
1 Q9P5N2 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9URZ4 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q9P5N2 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9URZ4 (/IC)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 B5BP45 (/ISM)
Cell division site GO:0032153
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
1 Q9URZ4 (/IDA)
Medial membrane band GO:0032178
A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum.
1 Q9URZ4 (/IDA)
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