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CATH Superfamily 1.10.533.10

Death Domain, Fas

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Death Domain, Fas
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Unc-5 netrin receptor B
931
3D
 1wmgF00 - 94.4
2
Ankyrin-3 isoform 2
670
3D
 4o6xB00 - 94.2
3
Caspase recruitment domain family, member 11
495
3D
 4i16A00 - 95.3
4
Death effector domain-containing protein-like
183 - - 76.3
5
Tumor necrosis factor receptor superfamily member 21
174
3D
 2dbhA01 - 39.0
6
Tumor necrosis factor receptor superfamily member EDAR
168 - - 40.6
7
death domain-containing protein CRADD isoform X1
162
3D
 3crdA00 - 77.0
13
Apoptosis-associated speck-like protein containing a CARD
160
3D
 6n1hP00 - 95.9
8
Death associated protein kinase 1
159 - - 60.0
9
tumor necrosis factor receptor superfamily member 21
154 - - 75.0
10
Ankyrin 1
150
3D
 2yviA00 - 70.1
14
Apoptotic protease-activating factor 1
149
3D
 5wvcE00 - 69.8
11
Myeloid cell nuclear differentiation antigen
138
3D
 2dbgA00 - 96.2
12
baculoviral IAP repeat-containing protein 2
135
3D
 3t6pA03 - 78.4
15
Caspase recruitment domain-containing protein 19
132
3D
 4fh0B00 - 83.3
16
CASP8 and FADD-like apoptosis regulator
128 - - 94.7
17
caspase-8 isoform X1
126
3D
 4zbwB01 - 72.3
18
Nuclear factor NF-kappa-B p105 subunit isoform 1
118
3D
 2dbfA01 - 52.5
19
NACHT, LRR and PYD domains-containing protein 3
116
3D
 3qf2B00 - 52.3
20
CASP8 and FADD like apoptosis regulator
108 - - 77.5
21
caspase-8 isoform X1
104
3D
 4zbwB02 - 79.9
28
Interleukin 1 receptor-associated kinase 4
101
3D
 3mopJ00 - 84.7
29
Myeloid differentiation primary response protein MyD88
101
3D
 3mopF00 - 97.2
22
B-cell lymphoma/leukemia 10
99
3D
 2mb9A00 - 81.9
23
DNA-binding death effector domain-containing protein 2
98 - - 70.4
53
Apoptosis-associated speck-like protein containing a CARD
98
3D
 2n1fO00 - 80.6
24
caspase-2 isoform X1
98 - - 91.7
25
THO complex subunit 1
98
3D
 1wxpA01 - 71.7
30
Interleukin-1 receptor-associated kinase-like 2
96
3D
 3mopN00 - 93.2
26
astrocytic phosphoprotein PEA-15 isoform X1
96
3D
 1n3kA00 - 15.1
34
tumor necrosis factor receptor superfamily member 16
95
3D
 2n97B00 - 75.0
27
Interleukin-1 receptor-associated kinase 1
Predicted
95 - - 72.7
33
p53-induced death domain-containing protein 1 isoform X1
93
3D
 2of5L00 - 72.3
31
Caspase 1, isoform CRA_b
93
3D
 1dgnA00 - 97.9
63
Mitochondrial antiviral-signaling protein
90
3D
 2vgqA03 - 94.8
32
Nucleotide-binding oligomerization domain-containing protein 2
89 - - 66.3
35
nucleolar protein 3 isoform X5
87
3D
 4uz0B00 - 40.5
41
Caspase 9
86
3D
 5wvcF00 - 89.2
37
Receptor-interacting serine/threonine-protein kinase 2
85
3D
 2n7zA00 - 86.9
36
Ankyrin 2, isoform M
84 - - 14.4
39
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
83
3D
 2g7rB00 - 76.0
38
Caspase 10
82 - - 94.9
47
Nucleotide-binding oligomerization domain-containing protein 1
81
3D
 4jqwA00 - 77.6
40
tumor necrosis factor receptor superfamily member 25
80 - - 36.0
42
Tumor necrosis factor receptor type 1-associated DEATH domain protein
79 - - 48.0
43
Tumor necrosis factor receptor superfamily member 10A
78 - - 94.7
44
Tumor necrosis factor receptor superfamily member 1A
75
3D
 1ichA00 - 85.6
45
Nucleotide-binding oligomerization domain-containing protein 2
72 - - 73.0
56
NACHT, LRR and PYD domains-containing protein 14
71
3D
 4ewiB00 - 79.9
46
Si:ch211-196f19.1
70 - - 81.6
48
MEFV, pyrin innate immunity regulator
69
3D
 2mpcA00 - 65.9
59
Fas-associated via death domain
69
3D
 1fadA00 - 97.0
57
Tumor necrosis factor receptor superfamily member 6
67
3D
 3ezqO00 - 76.7
49
NLR family pyrin domain containing 1
67
3D
 1pn5A00 - 68.9
50
E3 ubiquitin-protein ligase XIAP
66 - - 71.8
58
death domain-containing protein CRADD isoform X1
64
3D
 2of5G00 - 79.5
51
Baculoviral IAP repeat containing 2
64 - - 57.7
52
Putative receptor-interacting serine/threonine-protein kinase 1
63 - - 73.0
55
Interleukin-1 receptor-associated kinase 3
60 - - 71.6
54
Unc-5 family C-terminal like
60 - - 42.4
69
NACHT, LRR and PYD domains-containing protein 6
58
3D
 6ncvV00 - 85.8
72
Probable ATP-dependent RNA helicase DDX58
57
3D
 4p4hH02 - 82.6
60
disks large homolog 5 isoform X2
55 - - 13.1
62
Fas-associated via death domain
55
3D
 2gf5A01 - 86.6
61
nuclear factor NF-kappa-B p100 subunit isoform X1
55
3D
 2d96A01 - 62.0
78
Probable ATP-dependent RNA helicase DDX58
51
3D
 4p4hH01 - 87.1
64
NLR family pyrin domain containing 12
49
3D
 2l6aA00 - 67.8
66
Tumor necrosis factor receptor superfamily member 11B
43 - - 44.4
65
Ectodysplasin-A receptor-associated adapter protein
43 - - 81.0
67
NLR family pyrin domain containing 2
42 - - 79.0
68
NLR family CARD domain containing 4
37 - - 76.9
70
Caspase 10
36 - - 61.2
71
NACHT, LRR and PYD domains-containing protein 5
32 - - 42.9
73
Inactive caspase-12
32 - - 98.4
74
NLR family pyrin domain containing 7
32
3D
 2km6A00 - 34.1
76
Interferon-inducible protein AIM2
32
3D
 4o7qA00 - 94.7
75
Baculoviral IAP repeat containing 7
30 - - 70.7
79
IGF like family receptor 1
28 - - 74.3
77
Interferon-induced helicase C domain-containing protein 1
28 - - 42.7
80
Uncharacterized protein
26 - - 99.5
81
Apoptotic protease-activating factor 1
25 - - 98.2
82
Uncharacterized protein
24 - - 58.5
83
Leucine rich repeats and death domain containing 1
21 - - 44.2
84
Interferon-induced with helicase C domain 1
21 - - 73.9
85
Baculoviral IAP repeat containing 7
20 - - 47.8
86
AO66 ankyrin
19 - - 14.6
87
Uncharacterized protein
19 - - 81.6
88
P53-induced death domain protein 1
18 - - 99.2
90
Caspase recruitment domain family member 8
17 - - 70.5
89
E3 ubiquitin-protein ligase TTC3
17 - - 10.8
91
NLR family pyrin domain containing 10
16
3D
 2m5vA00 - 45.2
94
Interleukin-1 receptor-associated kinase
15 - - 95.8
93
Death-associated protein kinase dapk-1
15 - - 1.3
92
Netrin receptor unc-5
15 - - 67.0
95
Predicted protein
13 - - 90.6
96
Neurotrophin receptor associated death domain
12 - - 69.9
99
Uncharacterized protein
11 - - 96.1
101
Receptor-interacting serine/threonine kinase 1
11 - - 73.4
97
Death effector domain-containing 1
11 - - 35.7
100
NLR family pyrin domain containing 11
11 - - 0.0
98
Hematopoietic death receptor
11 - - 67.5
102
Imd
10 - - 21.3
103
MALT1 paracaspase
10 - - 24.4
104
Si:dkey-103e21.5
10 - - 80.8
107
Nucleotide-binding oligomerization domain-containing protein 1
9 - - 42.5
105
Fas-associated death domain protein
9 - - 37.5
106
Unc-5, isoform B
9 - - 9.9
110
astrocytic phosphoprotein PEA-15 isoform X2
8 - - 0.0
151
Viral CASP8 and FADD-like apoptosis regulator
8
3D
 2bbzD01 - 0.0
114
Caspase Dronc
8 - - 93.2
109
GG10810
8 - - 79.2
108
THO complex 1
8 - - 38.7
112
Uncharacterized protein
8 - - 23.9
111
astrocytic phosphoprotein PEA-15 isoform X2
8 - - 0.0
115
Uncharacterized protein
8 - - 75.5
113
Baculoviral IAP repeat-containing 3
8 - - 47.9
149
Viral CASP8 and FADD-like apoptosis regulator
7
3D
 2bbzD02 - 0.0
156
Cell death protein 4
7
3D
 4m9xA01 - 19.8
119
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
6 - - 18.4
118
TUBE
6 - - 77.3
130
Protein Tube
6
3D
 1d2zD00 - 11.4
116
Caspase-15
6 - - 72.3
117
Uncharacterized protein
6 - - 42.1
140
Death domain-containing membrane protein NRADD
6
3D
 6hj7A00 - 67.7
128
Uncharacterized protein
5 - - 74.3
129
Predicted protein
5 - - 84.9
139
Ankyrin-2
5
3D
 4d8oA04 - 14.3
124
Uncharacterized protein
5 - - 82.1
126
Tumor necrosis factor receptor superfamily, member 1a
5 - - 13.8
120
B-cell lymphoma/leukemia 10-like
5 - - 13.9
121
Uncharacterized protein
5 - - 10.8
122
Caspase 8a
5 - - 2.8
127
Uncharacterized protein
5 - - 72.2
123
Nerve growth factor receptor b
5 - - 31.1
125
Uncharacterized protein
5 - - 72.5
138
Interleukin-1 receptor-associated kinase 4
4 - - 11.3
142
Uncharacterized protein
4 - - 53.0
141
Uncharacterized protein
4 - - 34.7
134
Netrin receptor unc-5
4 - - 4.9
136
Interferon-induced with helicase C domain 1
4 - - 0.0
143
Caspase 8, apoptosis-related cysteine peptidase,-like 2
4 - - 1.4
131
Fas-associated death domain protein
4 - - 42.8
132
Cell death protein 3
4 - - 23.7
137
Uncharacterized protein
4 - - 19.1
133
Caspase b
4 - - 21.9
144
Apoptosis-associated speck-like protein-containing a CARD
4 - - 27.6
135
SBP
S-ribonuclease binding protein
4 - - 71.4
173
Predicted protein
3 - - 81.2
175
Apoptotic protease-activating factor, putative
3 - - 79.0
155
Zgc:194469
3 - - 0.0
147
Uncharacterized protein
3 - - 7.6
153
Caspase-8
3 - - 2.2
163
Putative BOI-related E3 ubiquitin-protein ligase 3
3 - - 8.9
165
Ankyrin
3 - - 1.3
167
Nerve growth factor receptor
3 - - 5.4
171
Uncharacterized protein
3 - - 10.9
172
X-linked inhibitor of apoptosis
3 - - 6.6
145
Uncharacterized protein
3 - - 67.4
157
NALP2
3 - - 21.4
152
Caspase-8
3 - - 27.6
161
Uncharacterized protein
3 - - 13.0
162
Myeloid differentiation primary response protein MyD88
3 - - 1.1
174
Caspase 9
3 - - 45.8
176
Baculoviral IAP repeat-containing protein 7
3 - - 74.1
148
CASP2 and RIPK1 domain containing adaptor with death domain
3 - - 5.2
170
Uncharacterized protein
3 - - 13.7
154
Uncharacterized protein
3 - - 12.7
160
Uncharacterized protein
3 - - 0.0
164
Cyclin T-dependent kinase CDK9, putative
3 - - 5.6
150
CASP2 and RIPK1 domain containing adaptor with death domain
3 - - 2.6
166
Melanoma differentiation associated gene 5
3 - - 9.4
146
Caspase recruitment domain family, member 6
3 - - 10.5
159
Predicted protein
3 - - 69.8
158
Baculoviral IAP repeat-containing protein 7
3 - - 22.6
168
NOD2b protein
3 - - 0.0
169
Guanylate-binding protein 4
3 - - 4.2
202
Uncharacterized protein
2 - - 0.0
228
Predicted protein
2 - - 0.0
192
Uncharacterized protein
2 - - 1.2
191
V-FLIP
2 - - 4.1
201
Caspase
2 - - 2.2
229
Uncharacterized protein
2 - - 5.4
219
Predicted protein
2 - - 1.3
186
Uncharacterized protein
2 - - 0.0
197
V-FLIP
2 - - 2.9
184
Uncharacterized protein
2 - - 0.0
218
Ankyrin-3
2 - - 0.0
207
Predicted protein
2 - - 39.9
180
Si:dkeyp-97b10.3
2 - - 0.0
234
Uncharacterized protein
2 - - 5.9
236
Predicted protein
2 - - 47.4
220
Predicted protein
2 - - 0.0
205
Uncharacterized protein
2 - - 10.1
224
Importin subunit alpha-7
2 - - 1.3
195
MC160
2 - - 3.9
203
CARD15
2 - - 11.5
230
Putative BOI-related E3 ubiquitin-protein ligase 3
2 - - 0.0
226
Uncharacterized protein
2 - - 7.5
193
Predicted protein
2 - - 2.7
216
Tumor necrosis factor receptor superfamily member 6
2 - - 0.0
189
Predicted protein
2 - - 0.0
188
Uncharacterized protein
2 - - 1.3
214
Predicted protein
2 - - 4.1
177
CARD domain-containing protein E10
2 - - 0.0
210
Uncharacterized protein
2 - - 0.0
231
Predicted protein
2 - - 4.7
232
interleukin-1 receptor-associated kinase 4
2 - - 0.0
209
Uncharacterized protein
2 - - 45.5
221
E3 ubiquitin-protein ligase HERC2
2 - - 0.0
199
Uncharacterized protein
2 - - 0.0
198
Uncharacterized protein
2 - - 0.0
208
CARD- and ANK-containing Inflammasome Adaptor Protein
2 - - 45.0
217
Fas cell surface death receptor
2 - - 3.8
222
NLR family, CARD domain-containing 3-like 1
2 - - 0.0
212
Predicted protein
2 - - 5.0
227
Si:dkey-61p9.9
2 - - 0.0
185
Uncharacterized protein
2 - - 12.7
183
Predicted protein
2 - - 0.0
211
Uncharacterized protein
2 - - 0.0
237
Uncharacterized protein
2 - - 43.3
178
THO complex subunit 1 isoform X1
2 - - 0.0
233
Ssl-1
2 - - 1.1
200
Uncharacterized protein
2 - - 0.0
190
Predicted protein
2 - - 1.3
235
Uncharacterized protein
2 - - 38.2
179
Uncharacterized protein
2 - - 2.4
206
Death-associated inhibitor of apoptosis 2
2 - - 41.1
196
Apoptosis-associated speck-like protein containing a CARD
2 - - 0.0
223
Uncharacterized protein
2 - - 6.5
194
Protein MC160
2 - - 9.6
187
Uncharacterized protein
2 - - 2.5
204
Uncharacterized protein
2 - - 21.3
225
Uncharacterized protein
2 - - 1.3
215
Uncharacterized protein
2 - - 0.0
182
Si:dkeyp-97b10.3
2 - - 2.5
181
Putative nuclear matrix protein
2 - - 10.2
213
Tumor necrosis factor receptor superfamily, member 1a
2 - - 0.0
242
Uncharacterized protein
1 - - 0.0
292
Predicted protein
1 - - 0.0
238
Uncharacterized protein
1 - - 0.0
239
Uncharacterized protein
1 - - 0.0
241
Uncharacterized protein
1 - - 0.0
307
Interleukin 1 receptor associated kinase 1
1 - - 0.0
291
Uncharacterized protein
1 - - 0.0
273
Uncharacterized protein
1 - - 0.0
275
Uncharacterized protein
1 - - 0.0
280
Uncharacterized protein
1 - - 0.0
263
Uncharacterized protein
1 - - 0.0
265
Uncharacterized protein
1 - - 0.0
255
Uncharacterized protein
1 - - 0.0
286
Uncharacterized protein
1 - - 0.0
302
Uncharacterized protein
1 - - 0.0
253
Uncharacterized protein
1 - - 0.0
301
Uncharacterized protein
1 - - 0.0
247
Uncharacterized protein
1 - - 0.0
297
Predicted protein
1 - - 0.0
284
NLR family, CARD domain-containing 3-like
1 - - 0.0
245
Uncharacterized protein
1 - - 0.0
295
Uncharacterized protein
1 - - 0.0
316
Uncharacterized protein
1 - - 0.0
293
NLR family CARD domain containing 3
1 - - 0.0
243
Uncharacterized protein
1 - - 0.0
257
Uncharacterized protein
1 - - 0.0
314
Uncharacterized protein
1 - - 0.0
310
Uncharacterized protein
1 - - 0.0
267
Uncharacterized protein
1 - - 0.0
271
Tumor necrosis factor receptor superfamily member 10b
1 - - 0.0
272
Uncharacterized protein
1 - - 0.0
277
Si:ch211-108d22.2
1 - - 0.0
261
Uncharacterized protein
1 - - 0.0
262
Uncharacterized protein
1 - - 0.0
289
Uncharacterized protein
1 - - 0.0
305
Retinoic acid-inducible protein Ia
1 - - 0.0
252
Uncharacterized protein
1 - - 0.0
303
Apoptosis 2 inhibitor-like Protein
1 - - 0.0
251
Caspase 10
1 - - 0.0
288
I Kappa B homolog
1 - - 0.0
312
Uncharacterized protein
1 - - 0.0
249
Uncharacterized protein
1 - - 0.0
299
NACHT, LRR and PYD domains-containing protein 9B
1 - - 0.0
270
Uncharacterized protein
1 - - 0.0
311
Uncharacterized protein
1 - - 0.0
248
Uncharacterized protein
1 - - 0.0
298
Uncharacterized protein
1 - - 0.0
274
Si:ch211-112c15.8
1 - - 0.0
276
Predicted protein
1 - - 0.0
250
Uncharacterized protein
1 - - 0.0
264
Uncharacterized protein
1 - - 0.0
266
Baculoviral IAP repeat containing 7
1 - - 0.0
309
Uncharacterized protein
1 - - 0.0
256
Uncharacterized protein
1 - - 0.0
285
Uncharacterized protein
1 - - 0.0
283
Uncharacterized protein
1 - - 0.0
260
Uncharacterized protein
1 - - 0.0
308
Retinoic acid-inducible protein Ia
1 - - 0.0
254
CASP8 and FADD-like apoptosis regulator a
1 - - 0.0
246
Uncharacterized protein
1 - - 0.0
296
Uncharacterized protein
1 - - 0.0
315
Uncharacterized protein
1 - - 0.0
313
Baculoviral IAP repeat containing 7
1 - - 0.0
244
Si:dkey-265e15.2
1 - - 0.0
294
Uncharacterized protein
1 - - 0.0
287
Uncharacterized protein
1 - - 0.0
290
Predicted protein
1 - - 0.0
240
Uncharacterized protein
1 - - 0.0
278
Uncharacterized protein
1 - - 0.0
279
Predicted protein
1 - - 0.0
300
Uncharacterized protein
1 - - 0.0
268
Predicted protein
1 - - 0.0
269
Uncharacterized protein
1 - - 0.0
259
Uncharacterized protein
1 - - 0.0
306
Uncharacterized protein
1 - - 0.0
282
Uncharacterized protein
1 - - 0.0
281
Putative inhibitor of apoptosis
1 - - 0.0
258
Caspase-8
1 - - 0.0
304
Uncharacterized protein
1 - - 0.0
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