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CATH Superfamily 1.10.30.10

High mobility group box domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
High mobility group box domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
transcription factor 7 isoform X2
1842
3D
 2lefA00 - 70.9
2
transcription factor Sox-2
1466
3D
 2gzkA01 - 96.7
3
Putative transcription factor SOX-6
1270
3D
 1i11A00 - 93.8
4
Transcription factor SOX-10
759 - - 74.7
5
TOX high mobility group box family member 3
662
3D
 2co9A00 - 81.0
6
High mobility group protein B1
565
3D
 2yrqA01 - 93.6
7
Transcription factor SOX
515
3D
 3u2bC00 - 77.2
8
transcription factor SOX-7
446
3D
 3f27D00 - 74.8
9
Histone-lysine N-methyltransferase
440
3D
 2yukA00 - 91.1
10
Capicua transcriptional repressor b
401 - - 58.6
11
Putative SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
335 - - 70.4
12
axial regulator YABBY 5-like
311 - - 63.1
13
High mobility group protein B3
283
3D
 2eqzA00 - 98.9
14
HMG box transcription factor BBX
280
3D
 1wz6A01 - 75.6
15
high mobility group protein B1
270
3D
 2gzkA02 - 98.0
16
FACT complex subunit SSRP1
232
3D
 1lwmA00 - 98.1
17
high mobility group protein B3
225
3D
 2yqiA00 - 97.0
18
High mobility group protein B2
203
3D
 1j3dA00 - 93.0
19
nucleolar transcription factor 1 isoform X2
175
3D
 1k99A00 - 28.0
20
HMG box-containing protein 1
160
3D
 2e6oA00 - 23.4
21
nucleolar transcription factor 1 isoform X1
151
3D
 1v64A00 - 34.6
22
nucleolar transcription factor 1 isoform X2
145
3D
 1v63A00 - 68.5
23
nucleolar transcription factor 1 isoform X2
141
3D
 2hdzA00 - 29.4
24
Histone-lysine N-methyltransferase NSD2
127 - - 86.6
25
HMG domain-containing protein 3 isoform X2
125 - - 15.7
26
PMS1 homolog 1, mismatch repair system component
121
3D
 2cs1A00 - 98.3
28
WD repeat and HMG-box DNA-binding protein 1
118
3D
 2d7lA01 - 100.0
27
Transcription factor SOX-30
117 - - 83.9
29
nucleolar transcription factor 1 isoform X2
106 - - 27.1
30
HMG domain-containing protein 4 isoform X1
103 - - 49.2
31
High mobility group protein 20A
102 - - 22.0
32
FACT complex subunit SSRP1
99 - - 46.5
33
nucleolar transcription factor 1 isoform X1
91 - - 40.7
34
SWI/SNF-related matrix-associated regulator of chromatin subfamily E member 1-related
88 - - 28.5
35
Maelstrom spermatogenic transposon silencer
74
3D
 2ctoA01 - 76.6
36
high mobility group protein D
73
3D
 1wxlA00 - 85.2
37
High mobility group protein B2
61 - - 80.0
43
Transcription factor A, mitochondrial
57
3D
 4nodH02 - 89.5
38
High mobility group box 4
54 - - 86.1
39
protein CRABS CLAW isoform X3
53 - - 48.3
40
SRY
sex determining region Y
52 - - 35.4
41
HMG box family protein
48 - - 92.7
45
Transcription factor A, mitochondrial
47
3D
 4nodH01 - 62.9
42
High mobility group protein 1.2
47 - - 88.0
44
High mobility group B1
46 - - 71.9
46
High mobility group box 4
38 - - 90.2
47
Axial regulator YABBY
34 - - 64.2
48
Putative SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member
27 - - 71.1
49
Related to NHP6B-nonhistone chromosomal protein
24 - - 76.4
50
Nuclear autoantigen Sp-100
23 - - 71.8
51
Transcription factor Sox-10
21 - - 42.6
52
Non-histone chromosomal protein 6 homolog
21 - - 72.4
55
High mobility group B protein 15
19 - - 77.1
56
Brahma-associated protein 111kD
19 - - 93.7
54
Swi snf-related matrix-associated actin-dependent regulator of
19 - - 83.9
53
Protein CRABS CLAW
19 - - 39.2
57
Protein maelstrom 2
17 - - 85.3
58
IXR1p Transcriptional repressor
16 - - 20.3
59
Protein pop-1
15 - - 76.0
64
Mutant transcription factor sox9a
15
3D
 4s2qD00 - 36.4
60
Transcription factor protein
15 - - 91.6
62
Hmg-1.1
15 - - 89.2
61
High mobility group protein B3
15 - - 15.7
63
High mobility group protein B3
14 - - 12.3
66
High mobility group family
13 - - 4.0
68
PolyBRoMo domain containing
13 - - 23.0
67
Lysine-specific histone demethylase Aof2, putative
13 - - 87.5
65
Nhp10p
13 - - 47.2
70
Uncharacterized protein, isoform A
12 - - 16.1
71
High mobility group protein
12 - - 78.5
69
CBL-interacting protein kinase 33
12 - - 10.0
73
High mobility group protein 1 homolog
11 - - 90.6
72
FACT complex subunit SSRP1
11 - - 69.4
74
SRY-related protein AMA1
10 - - 32.4
81
High mobility group protein B4, putative
10 - - 12.7
76
Axial regulator YABBY 4
10 - - 71.8
78
ARS-binding factor
10 - - 0.0
77
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
10 - - 20.5
75
Capicua transcriptional repressor a
10 - - 41.2
80
ARS-binding factor
10 - - 0.0
79
IXR1p Transcriptional repressor
10 - - 16.7
83
High mobility group B protein 13
9 - - 44.4
82
Mitochondrial transcription factor A, isoform B
9 - - 15.2
85
Chromatin-associated protein
8 - - 16.4
84
HMG type nucleosome/chromatin assembly factor
8 - - 30.4
86
Protein CBG16280
8 - - 76.9
87
Uncharacterized protein
7 - - 9.7
88
Sex-determining region Y protein
6 - - 18.0
91
HMG
High mobility group
6 - - 4.1
144
High mobility group protein B1
6
3D
 1nhnA00 - 41.1
89
high mobility group B protein 7 isoform X1
6 - - 50.6
93
AGAP002022-PA
6 - - 93.6
92
High mobility group B protein 13
6 - - 63.5
90
High mobility group protein 2
6 - - 10.9
97
Similar to transcription factor HMG
5 - - 8.3
95
High mobility group protein-like tdp-1, putative
5 - - 8.8
94
High mobility group B protein 4
5 - - 37.6
96
Chromodomain helicase DNA binding protein 3
5 - - 11.5
101
Testis-enriched HMG-box-containing protein 1
4 - - 20.2
98
Uncharacterized protein
4 - - 45.5
103
HMG box-containing protein
4 - - 12.4
104
Transcription factor SOX-2
4 - - 21.5
102
Transcription factor Sox-7
4 - - 10.1
100
Sex-determining region Y protein
4 - - 58.1
99
Axial regulator YABBY 4
4 - - 13.0
106
Zgc:165618 protein
4 - - 50.6
110
Polybromo 1
4 - - 50.4
108
High mobility group protein-like tdp-1, putative
4 - - 5.1
107
transcription factor protein
4 - - 4.9
109
Lysine-specific histone demethylase Aof2
4 - - 4.7
105
High mobility group
HMG
4 - - 7.0
121
LD26355p
3 - - 6.7
115
AGAP005183-PA
3 - - 1.7
119
High mobility group protein homolog TDP-1
3 - - 0.0
120
protein polybromo-1 isoform X1
3 - - 1.3
118
High mobility group protein homolog TDP-1
3 - - 0.0
117
Uncharacterized protein
3 - - 6.0
122
PMS1 homolog 1, mismatch repair system component
3 - - 9.5
123
FACT complex subunit SSRP1
3 - - 40.2
116
HMG box-containing protein 1
3 - - 2.8
114
Gcf1p
3 - - 0.0
112
Transcription factor 7-like 2
3 - - 10.0
113
GH11850p
3 - - 12.8
111
Protein CBG16744
3 - - 61.9
143
Protein CBG07235
2 - - 46.9
136
HMG1/2
High mobility group
2 - - 23.5
130
Uncharacterized protein
2 - - 12.5
142
PMS1 homolog 1, mismatch repair system component
2 - - 1.4
140
FACT complex subunit SSRP1
2 - - 0.0
132
HMG box protein, putative
AFU_orthologue AFUA_1G10040
2 - - 0.0
134
Uncharacterized protein
2 - - 0.0
133
Protein CBG16280
2 - - 5.6
141
YALI0D26972p
2 - - 0.0
126
Uncharacterized protein
2 - - 0.0
124
Uncharacterized protein
2 - - 31.0
131
HMG box protein, putative
AFU_orthologue AFUA_1G10040
2 - - 0.0
125
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
2 - - 0.0
129
High mobility group-T protein
2 - - 0.0
127
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
2 - - 0.0
128
High mobility group protein
2 - - 49.6
135
Uncharacterized protein
2 - - 42.4
139
Polybromo-1
2 - - 2.1
138
Isw-1
2 - - 3.1
137
Histone-lysine N-methyltransferase
2 - - 0.0
155
Uncharacterized protein
1 - - 0.0
159
Uncharacterized protein
1 - - 0.0
175
Uncharacterized protein
1 - - 0.0
161
HMG box-containing protein C28F2.11
1 - - 0.0
179
Uncharacterized protein
1 - - 0.0
197
Uncharacterized protein
1 - - 0.0
198
PHDfinger domain-containing protein
1 - - 0.0
157
Uncharacterized protein
1 - - 0.0
158
HMG box family protein
1 - - 0.0
146
Protein CBG08365
1 - - 0.0
178
High mobility group protein
1 - - 0.0
177
AFL219Wp
1 - - 0.0
199
Uncharacterized protein
1 - - 0.0
195
FACT complex subunit SSRP1
1 - - 0.0
164
Maelstrom
1 - - 0.0
162
HMG box-containing protein C19G7.04
1 - - 0.0
187
HMG
1 - - 0.0
163
Protein maelstrom
1 - - 0.0
188
Upstream-binding factor 1-like protein 1
1 - - 0.0
160
FACT complex subunit SSRP1
1 - - 0.0
185
Uncharacterized protein
1 - - 0.0
166
Uncharacterized protein
1 - - 0.0
189
Predicted protein
1 - - 0.0
167
Uncharacterized protein
1 - - 0.0
183
Uncharacterized protein
1 - - 0.0
168
Uncharacterized protein
1 - - 0.0
191
HMG
1 - - 0.0
201
Uncharacterized protein
1 - - 0.0
182
Uncharacterized protein
1 - - 0.0
184
Uncharacterized protein
1 - - 0.0
165
Uncharacterized protein
1 - - 0.0
186
Uncharacterized protein
1 - - 0.0
171
HMG box-containing protein C10F6.08c
1 - - 0.0
180
Uncharacterized protein
1 - - 0.0
169
Uncharacterized protein
1 - - 0.0
151
Kinetoplast-associated protein 4
1 - - 0.0
170
Uncharacterized protein
1 - - 0.0
202
Predicted protein
1 - - 0.0
181
High mobility group box 2
1 - - 0.0
176
Predicted protein
1 - - 0.0
193
FACT complex subunit SSRP1
1 - - 0.0
148
HMG box family protein
1 - - 0.0
192
Predicted protein
1 - - 0.0
150
Mismatch-binding protein cmb1
1 - - 0.0
147
Uncharacterized protein
1 - - 0.0
194
Putative high mobility group B protein 11
1 - - 0.0
156
SRY-box 18
1 - - 0.0
173
Chromosome 1, whole genome shotgun sequence
1 - - 0.0
154
Predicted protein
1 - - 0.0
196
Uncharacterized protein
1 - - 0.0
190
Predicted protein
1 - - 0.0
152
Uncharacterized protein
1 - - 0.0
145
Uncharacterized protein
1 - - 0.0
153
HMG transcription factor SoxC
1 - - 0.0
174
Predicted protein
1 - - 0.0
149
High mobility group protein C, putative
1 - - 0.0
172
High mobility group B protein 14
1 - - 0.0
200
Uncharacterized protein
1 - - 0.0
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