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CATH Superfamily 1.10.287.130

Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Two-component sensor histidine kinase
1043
3D
 4zkiB01 - 98.5
2
Two-component osmosensing histidine kinase
618 - - 95.6
3
Histidine kinase
529 - - 91.6
4
Ethylene receptor 1
442
3D
 4mtxD00 - 97.9
6
Osmolarity two-component histidine kinase EnvZ
425
3D
 3zrwC00 - 71.4
5
Nitrogen regulation histidine kinase
417 - - 63.6
8
Two-component sensor histidine kinase
320
3D
 6azrC01 - 96.6
7
Sensor histidine kinase CpxA
316
3D
 4biuE01 - 51.1
9
Two-component sensor histidine kinase
298 - - 76.1
10
Two-component sensor histidine kinase
295 - - 84.8
11
Sensor histidine kinase DcuS
292 - - 93.8
12
Histidine kinase
266 - - 54.0
13
Sensor histidine kinase PhoQ
245 - - 78.6
14
Signal transduction histidine-protein kinase BaeS
195 - - 70.8
15
Histidine kinase 4
178 - - 74.2
16
Aerobic respiration control sensor protein
175 - - 41.1
17
Two-component sensor histidine kinase
132 - - 32.0
18
Sensor histidine kinase RstB
124 - - 28.4
19
Sensor histidine kinase RcsC
124 - - 35.1
20
Sensor histidine kinase DpiB
116 - - 30.5
21
Sensor histidine kinase KdpD
110 - - 80.3
22
Two-component sensor CbrA
101 - - 37.2
23
Sensor histidine kinase/response regulator, putative
99 - - 90.8
24
Sensor histidine kinase/response regulator
96 - - 23.2
25
Histidine kinase 1-like protein
94 - - 81.4
26
Two-component system sensor histidine kinase PmrB
89 - - 54.7
28
Hybrid signal transduction histidine kinase
88 - - 72.8
29
Phytochrome
88 - - 71.5
27
Sensor histidine kinase KdpD
88 - - 70.2
30
Putative histidine kinase 5
86 - - 74.2
31
Two-component sensor histidine kinase
84 - - 71.9
33
Sporulation initiation phosphotransferase
83 - - 12.4
32
Sensor histidine kinase
83 - - 61.3
34
Two-component system sensor histidine kinase/response regulator
82 - - 97.6
35
Two-component sensor histidine kinase
79 - - 95.1
36
Two-component sensor histidine kinase
78 - - 78.3
37
Hybrid sensor histidine kinase/response regulator
72
3D
 5idjA01 - 84.8
38
Sensory transduction histidine kinase
67 - - 95.4
39
Sensor-like histidine kinase YfhK
61 - - 90.8
40
PAS domain-containing sensor histidine kinase
60 - - 84.2
44
LAO/AO transport system ATPase
59
3D
 2p67A03 - 12.4
43
Two-component sensor histidine kinase KdpD
59 - - 23.6
41
Two-component sensor histidine kinase
59 - - 30.7
42
Sensor protein
59 - - 1.0
45
Two-component system sensor histidine kinase/response regulator
57 - - 89.9
47
Two-component sensor histidine kinase
56 - - 61.5
46
Two-component sensor histidine kinase
56 - - 54.2
48
Sensor histidine kinase/response regulator
55 - - 62.2
49
C4-dicarboxylate transport sensor protein DctB
55 - - 97.1
51
Two-component system sensor histidine kinase CreC
54 - - 63.9
50
Related to histidine kinase
54 - - 73.1
58
Histidine phosphotransferase ChpT
49
3D
 4fppC01 - 60.9
52
PAS domain-containing sensor histidine kinase
49 - - 39.3
55
Two-component sensor histidine kinase
46
3D
 4gczB02 - 75.2
53
Two-component sensor histidine kinase
46 - - 33.5
54
Sensor histidine kinase
45 - - 33.8
56
Sensor histidine kinase
42 - - 27.5
57
Type IV pilus sensor protein PilS
40 - - 62.7
59
PAS domain-containing sensor histidine kinase
36 - - 31.8
61
Histidine kinase
35 - - 76.0
60
ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein
35 - - 37.1
67
Methylmalonic aciduria type A homolog, mitochondrial
34
3D
 2wwwD03 - 41.6
63
Hybrid sensor histidine kinase/response regulator
34 - - 86.8
62
Hybrid sensor histidine kinase/response regulator
34 - - 25.8
64
Sensor histidine kinase
33 - - 16.7
65
Histidine kinase
33 - - 58.5
66
PAS domain-containing sensor histidine kinase
31 - - 77.2
68
PAS domain-containing sensor histidine kinase
30 - - 89.9
70
Histidine kinase sensor protein
29 - - 86.8
69
Probable histidine kinase 1
29 - - 17.7
72
Hybrid sensor histidine kinase/response regulator
28 - - 26.0
71
Sensor histidine kinase
28 - - 5.0
74
Histidine kinase
26 - - 64.1
73
Two-component sensor histidine kinase
26 - - 79.8
75
Two-component sensor histidine kinase
24 - - 31.0
80
Sensor histidine kinase/response regulator EvgS
23 - - 69.2
78
Heme sensor histidine kinase HssS
23 - - 1.9
79
Unplaced genomic scaffold supercont1.240, whole genome shotgun sequence
23 - - 73.7
77
Sensor histidine kinase SaeS
23 - - 10.8
76
Two-component sensor histidine kinase
23 - - 17.5
81
Hybrid sensor histidine kinase/response regulator
20 - - 91.2
82
Sensor histidine kinase YvrG
19 - - 72.3
85
Signal transduction histidine-protein kinase atoS
19 - - 1.6
84
Sensor histidine kinase
19 - - 0.0
83
Putative two-component sensor histidine kinase
19 - - 57.6
87
Ethylene receptor 4
19 - - 97.5
86
Two-component system sensor histidine kinase/response regulator
19 - - 45.1
89
Sensor histidine kinase
18 - - 85.3
88
Two-component sensor histidine kinase
18 - - 40.8
91
Autoinducer 2 sensor kinase/phosphatase LuxQ
17 - - 80.8
92
Response regulator receiver domain protein
17 - - 44.4
90
Histidine kinase sensor protein
17 - - 16.0
103
Two-component sensor histidine kinase
17
3D
 4q20B01 - 27.8
95
Two-component sensor histidine kinase
16 - - 18.9
93
Two-component sensor histidine kinase
16 - - 8.9
94
Two-component sensor histidine kinase
16 - - 4.2
100
Sensor histidine kinase/response regulator
14 - - 78.5
99
Two-component sensor histidine kinase
14 - - 11.9
96
Two-component sensor histidine kinase
14 - - 30.7
97
Sensor histidine kinase
14 - - 18.0
98
Histidine kinase
14 - - 25.0
101
Sensor histidine kinase
14 - - 87.0
102
Two-component sensor histidine kinase
13 - - 27.9
105
Putative sensory histidine kinase in two-component regulatory system
13 - - 0.0
107
Sensor histidine kinase YycG
13 - - 79.4
104
Sensor histidine kinase
13 - - 0.0
106
Hybrid sensor histidine kinase/response regulator
13 - - 7.4
109
Sensor histidine kinase
12 - - 30.0
108
Two-component sensor histidine kinase
12 - - 19.1
110
Two-component system sensor histidine kinase/response regulator
12 - - 52.1
113
PAS/PAC sensor hybrid histidine kinase
11 - - 76.1
112
Sensor histidine kinase
11 - - 15.1
111
Two-component sensor histidine kinase
11 - - 20.1
117
Sensor histidine kinase
10 - - 11.7
118
Hybrid sensor histidine kinase/response regulator
10 - - 23.1
120
RteA, two-component system histidine kinase, with response regulator receiver domain
10 - - 71.2
116
Sensor histidine kinase
10 - - 0.0
121
Histidine kinase sensor protein
10 - - 81.3
114
Sensor histidine kinase RegB
10 - - 29.5
119
Unplaced genomic scaffold supercont1.240, whole genome shotgun sequence
10 - - 13.3
115
Histidine kinase
10 - - 14.8
122
Sensor histidine kinase
9 - - 23.9
125
Signal transduction histidine kinase
9 - - 39.9
127
Two-component sensor histidine kinase
9 - - 79.5
123
Probable two-component sensor
9 - - 0.0
128
Sensory box sensor histidine kinase
9 - - 41.3
124
Two-component system, OmpR family, sensor histidine kinase KdpD
9 - - 47.7
126
Related to SLN1-histidine kinase osmosensor that regulates a MAP kinase cascade
9 - - 17.5
133
Sensory box sensor histidine kinase
8 - - 10.1
129
Two-component sensor, ParS
8 - - 0.0
132
Sensory transduction histidine kinase
8 - - 39.1
130
Signal transduction histidine kinase
8 - - 14.3
131
Sensor histidine kinase
8 - - 24.3
137
Sensor histidine kinase YbdK
7 - - 27.6
138
Sensor histidine kinase
7 - - 4.2
143
Two-component system sensor histidine kinase
7 - - 12.5
144
Two-component sensor histidine kinase
7 - - 77.2
134
Two-component sensor histidine kinase
7 - - 0.0
136
Histidine kinase
7 - - 72.7
135
Sensor histidine kinase
7 - - 1.1
140
Sensor histidine kinase, PAS and GAF domain-containing
7 - - 83.5
142
Sensor histidine kinase
7 - - 0.0
145
Sensory transduction histidine kinase
7 - - 86.0
139
Sensor histidine kinase
7 - - 0.0
141
Sensor histidine kinase, KdpD
7 - - 0.0
158
Hybrid sensor histidine kinase/response regulator
6 - - 70.3
153
Sensor histidine kinase
6 - - 11.0
157
Two-component system sensor protein
6 - - 1.7
148
Two-component sensor EnvZ
6 - - 0.0
147
Protein-histidine kinase, putative
6 - - 8.2
156
Probable two-component sensor
6 - - 4.8
154
Adaptive-response sensory kinase
6 - - 81.4
146
PAS domain S-box protein
6 - - 0.0
159
Two-component sensor histidine kinase
6 - - 52.0
150
Two-component system sensor histidine kinase
6 - - 0.0
149
Sensor histidine kinase
6 - - 0.0
155
Histidine kinase, putative
6 - - 17.1
152
Sensor histidine kinase
6 - - 17.1
151
Sensor histidine kinase KdpD
6 - - 4.5
166
Two-component sensor histidine kinase
5 - - 3.1
176
Development and carotenogenesis control-1 protein
5 - - 5.7
164
Signal transduction histidine kinase
5 - - 19.1
174
Sensory box histidine kinase
5 - - 5.4
168
Sensor histidine kinase
5 - - 0.0
178
Sensory transduction histidine kinase
5 - - 40.0
163
Sensor histidine kinase
5 - - 9.0
173
Sensor histidine kinase/response regulator LuxN
5 - - 11.9
177
Hybrid sensor histidine kinase/response regulator
5 - - 1.9
167
Sensor histide kinase
5 - - 0.0
161
Histidine kinase A domain protein
5 - - 7.7
171
Integral membrane sensor signal transduction histidine kinase
5 - - 18.5
169
Sensor histidine kinase
5 - - 12.6
179
GAF sensor signal transduction histidine kinase
5 - - 53.1
180
Two-component hybrid sensor and regulator
5 - - 78.8
160
Two-component system, OmpR family, sensor kinase
5 - - 6.2
170
Volvoxopsin-5, sensory rhodopsin with histidine kinase domain
5 - - 2.5
165
Two-component hybrid sensor and regulator
5 - - 10.0
175
Sensory box histidine kinase SdeK
5 - - 11.3
162
Two component system histidine kinase
5 - - 15.4
172
Two-component hybrid sensor and regulator
5 - - 5.4
184
Sensor histidine kinase
4 - - 1.9
194
Sensor histidine kinase, PAS, PAS and PAS domain-containing
4 - - 36.3
186
Bacteriophytochrome
4 - - 0.0
193
Sensory transduction histidine kinase
4 - - 65.8
183
Histidine kinase
4 - - 6.2
187
PAS domain-containing sensor histidine kinase
4 - - 0.0
188
Sensor protein atoS
4 - - 7.7
191
Histidine kinase
4 - - 6.3
181
HAMP domain-containing histidine kinase
4 - - 0.0
185
Bacteriophytochrome protein
4 - - 15.6
182
Histidine kinase sensor protein
4 - - 3.3
190
Sensor histidine kinase/response regulator
4 - - 8.1
192
Histidine kinase
4 - - 50.8
189
Sensory box sensor histidine kinase/response regulator VieS
4 - - 1.8
196
Histidine kinase
3 - - 0.0
201
Phosphate regulon sensor protein PhoR
SphS
3 - - 3.1
214
Histidine kinase
3 - - 54.5
198
Sensor histidine kinase
3 - - 7.1
213
Hybrid sensory kinase
3 - - 7.9
200
Probable two-component sensor histidine kinase VicK
3 - - 9.9
197
Sensor protein
3 - - 2.0
202
Integral membrane sensor signal transduction histidine kinase
3 - - 6.8
205
Two-component sensor histidine kinase
3 - - 0.0
209
Integral membrane sensor signal transduction histidine kinase
3 - - 11.9
211
Two-component sensor histidine kinase
3 - - 0.0
204
Sensor histidine kinase
3 - - 13.4
206
HAMP domain protein
3 - - 2.1
199
Two component signal transduction system histidine kinase
3 - - 6.3
212
Two-component hybrid sensor and regulator
3 - - 1.2
208
Two-component hybrid sensor and regulator
3 - - 3.1
207
GAF sensor signal transduction histidine kinase
3 - - 8.2
210
Sensor histidine kinase
3 - - 44.8
195
Hybrid sensory kinase
3 - - 10.6
203
Hybrid sensor kinase RscS
3 - - 7.5
244
Uncharacterized protein
2 - - 0.0
216
Two-component system sensor protein
2 - - 0.0
234
Sensor histidine kinase, Cache_1 and HAMP domain-containing
2 - - 5.7
221
Two-component system sensor histidine kinase
2 - - 0.0
246
Uncharacterized protein
2 - - 11.1
236
Sensor histidine kinase, PAS and GAF domain-containing
2 - - 0.0
217
Sensor histidine kinase, NtrB-related protein
2 - - 0.0
222
Hybrid signal transduction histidine kinase C
2 - - 1.7
225
Two-component hybrid sensor and regulator
2 - - 0.0
218
Ethylene response sensor 1
2 - - 0.0
220
Sensor histidine kinase
2 - - 0.0
237
Phytochrome-like protein cph1
2 - - 0.0
248
Hybrid sensory kinase
2 - - 0.0
233
Histidine kinase
2 - - 0.0
247
Hybrid signal transduction histidine kinase H
2 - - 8.9
229
Sensor histidine kinase
2 - - 1.5
238
Circadian input kinase A
2 - - 10.3
243
Histidine kinase
2 - - 0.0
251
Hybrid sensory kinase
2 - - 0.0
224
Histidine kinase
2 - - 4.9
231
ATP-binding region ATPase domain protein
2 - - 0.0
241
Sensor histidine kinase
2 - - 0.0
226
Two component system histidine kinase
2 - - 1.4
232
Globin-coupled histidine kinase
2 - - 8.8
240
Histidine kinase
2 - - 0.0
235
Regulatory components of sensory transduction system
2 - - 0.0
219
Sensory transduction histidine kinase
2 - - 0.0
242
Sensor histidine kinase, PAS domain-containing
2 - - 0.0
230
Sensor histidine kinase, HAMP domain-containing
2 - - 9.4
245
Sensory box sensor histidine kinase
2 - - 4.5
227
Two-component sensor kinase
2 - - 2.1
250
Response receiver histidine kinase
2 - - 0.0
249
Two-component hybrid sensor and regulator
2 - - 1.4
215
Sensory box histidine kinase
2 - - 7.1
223
GAF domain-containing protein
2 - - 0.0
228
Sensory transduction histidine kinase
2 - - 8.1
239
Two component signal transduction system histidine kinase with CHASE and PAS sensory domains
2 - - 10.3
252
ATP-binding region ATPase domain protein
2 - - 47.7
256
Sensor histidine kinase
1 - - 0.0
268
Sensor histidine kinase/response regulator
1 - - 0.0
263
Sensor histidine kinase, copper metabolism, putative
1 - - 0.0
273
Two-component hybrid sensor and regulator
1 - - 0.0
267
Periplasmic substrate-binding histidine kinase
1 - - 0.0
254
Histidine kinase A domain protein
1 - - 0.0
266
Putative two-component system sensor kinase/response regulator
1 - - 0.0
258
Sensor histidine kinase
1 - - 0.0
253
Two component signal transduction system histidine kinase
1 - - 0.0
257
Histidine kinase
1 - - 0.0
264
Two component system histidine kinase
1 - - 0.0
269
Uncharacterized protein
1 - - 0.0
260
Two-component sensor histidine kinase
1 - - 0.0
270
Sensory histidine protein kinase
1 - - 0.0
265
Histidine kinase
1 - - 0.0
262
Histidine kinase sensor protein
1 - - 0.0
272
BfiS
1 - - 0.0
259
Histidine kinase
1 - - 0.0
261
Phosphate regulon sensor protein PhoR
1 - - 0.0
271
Sensor histidine kinase, PAS domain-containing
1 - - 0.0
255
Two-component hybrid sensor and regulator
1 - - 0.0
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