CATH Domain 6mjxA01

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1410	Poly(a)-polymerase, middle domain
	1.10.1410.40

Superfamily	1.10.1410.40
Functional Family	Cyclic GMP-AMP synthase

2.7.7.86

Cyclic GMP-AMP synthase.

based on mapping to UniProt Q8N884

ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5').

-!- Cyclic Gp(2'-5')Ap(3'-5') is a signaling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.

CGAS_HUMAN

Homo sapiens

Cyclic GMP-AMP synthase

PDB	6MJX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Lama, L., Adura, C., Xie, W., Tomita, D., Kamei, T., Kuryavyi, V., Gogakos, T., Steinberg, J.I., Miller, M., Ramos-Espiritu, L., Asano, Y., Hashizume, S., Aida, J., Imaeda, T., Okamoto, R., Jennings, A.J., Michino, M., Kuroita, T., Stamford, A., Gao, P., Meinke, P., Glickman, J.F., Patel, D.J., Tuschl, T. Nat Commun