CATH Domain 6g5fA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1240	Zincin-like
	3.90.1240.10	Metalloproteases ("zincins"), catalytic domain like

Domain Context

CATH Clusters

Superfamily	Metalloproteases ("zincins"), catalytic domain like
Functional Family	Botulinum neurotoxin type B

Enzyme Information

3.4.24.69

Bontoxilysin.

based on mapping to UniProt P10844

Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.

-!- Belongs to peptidase family M27.

UniProtKB Entries (2)

P10844	BXB_CLOBO Clostridium botulinum Botulinum neurotoxin type B
P21579	SYT1_HUMAN Homo sapiens Synaptotagmin-1

PDB Structure

PDB	6G5F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models. Elliott, M., Favre-Guilmard, C., Liu, S.M., Maignel, J., Masuyer, G., Beard, M., Boone, C., Carre, D., Kalinichev, M., Lezmi, S., Mir, I., Nicoleau, C., Palan, S., Perier, C., Raban, E., Zhang, S., Dong, M., Stenmark, P., Krupp, J. Sci Adv