CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.4080 | ADP-ribosylglycohydrolase fold |
|
1.10.4080.10 | ADP-ribosylation/Crystallin J1 |
Domain Context
CATH Clusters
| Superfamily | ADP-ribosylation/Crystallin J1 |
| Functional Family | ADP-ribosylarginine hydrolase isoform X1 |
Enzyme Information
| 3.2.2.19 |
[Protein ADP-ribosylarginine] hydrolase.
based on mapping to UniProt P54922
(1) Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-D-ribose + protein-L-arginine. (2) N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-D-ribose + L-arginine.
-!- The enzyme will remove ADP-D-ribose from arginine residues in ADP- ribosylated proteins.
|
UniProtKB Entries (1)
| P54922 |
ADPRH_HUMAN
Homo sapiens
[Protein ADP-ribosylarginine] hydrolase
|
PDB Structure
| PDB | 6G28 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
(ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition.
Cell Chem Biol
|
