CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.170 | Elastase; domain 1 |
|
3.10.170.10 |
Domain Context
CATH Clusters
| Superfamily | 3.10.170.10 |
| Functional Family | Elastase |
Enzyme Information
| 3.4.24.26 |
Pseudolysin.
based on mapping to UniProt P14756
Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects.
-!- Causes tissue damage. -!- Belongs to peptidase family M4. -!- Formerly EC 3.4.24.4.
|
UniProtKB Entries (1)
| P14756 |
ELAS_PSEAE
Pseudomonas aeruginosa PAO1
Elastase
|
PDB Structure
| PDB | 6FZX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor.
ACS Chem. Biol.
|
