CATH Domain 6f1dA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.290	Spermadhesin, CUB domain

Domain Context

CATH Clusters

Superfamily	Spermadhesin, CUB domain
Functional Family	Mannan-binding lectin serine protease 1

Enzyme Information

3.4.21.41

Complement subcomponent C1r.

based on mapping to UniProt P00736

Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).

-!- Activates C1s by proteolytic cleavage so that it can, in turn, activate C2 and C4. -!- Activated from proenzyme C1r in plasma by autocatalytic mechanism during activation of the complement system by the 'classical' route. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00736

C1R_HUMAN

Homo sapiens

Complement C1r subcomponent

PDB Structure

PDB	6F1D
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of the C1r-C1s interaction of the C1 complex of complement activation. Almitairi, J.O.M., Venkatraman Girija, U., Furze, C.M., Simpson-Gray, X., Badakshi, F., Marshall, J.E., Schwaeble, W.J., Mitchell, D.A., Moody, P.C.E., Wallis, R. Proc. Natl. Acad. Sci. U.S.A.

Network disruptions