CATH Domain 6d85A00

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.555	Phosphatidylinositol 3-kinase; Chain A
	1.10.555.10	Rho GTPase activation protein

Domain Context

CATH Clusters

Superfamily	Rho GTPase activation protein
Functional Family	Phosphatidylinositol 3-kinase regulatory subunit alpha

Enzyme Information

UniProtKB Entries (1)

P85A_BOVIN

Bos taurus

Phosphatidylinositol 3-kinase regulatory subunit alpha

PDB Structure

PDB	6D85
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Patient-derived mutations within the N-terminal domains of p85 alpha impact PTEN or Rab5 binding and regulation. Mellor, P., Marshall, J.D.S., Ruan, X., Whitecross, D.E., Ross, R.L., Knowles, M.A., Moore, S.A., Anderson, D.H. Sci Rep