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1 keywords

CATH Domain 6ckxD02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.472 Cyclin A; domain 1
Homologous Superfamily 1.10.472.10 Cyclin-like

Domain Context

CATH Clusters

Superfamily Cyclin-like
Functional Family Cyclin-K (Predicted)

Enzyme Information

UniProtKB Entries (1)

O75909
CCNK_HUMAN
Homo sapiens
Cyclin-K

PDB Structure

PDB 6CKX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors.
Ito, M., Tanaka, T., Toita, A., Uchiyama, N., Kokubo, H., Morishita, N., Klein, M.G., Zou, H., Murakami, M., Kondo, M., Sameshima, T., Araki, S., Endo, S., Kawamoto, T., Morin, G.B., Aparicio, S.A., Nakanishi, A., Maezaki, H., Imaeda, Y.
J. Med. Chem.
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