CATH Domain 5zqyA00

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.4080	ADP-ribosylglycohydrolase fold
	1.10.4080.10	ADP-ribosylation/Crystallin J1

Domain Context

CATH Clusters

Superfamily	ADP-ribosylation/Crystallin J1
Functional Family	ADP-ribose glycohydrolase ARH3

Enzyme Information

3.2.2.-	Hydrolyzing N-glycosyl compounds. based on mapping to UniProt Q9NX46
3.2.1.143	Poly(ADP-ribose) glycohydrolase. based on mapping to UniProt Q9NX46 Hydrolyzes poly(ADP-D-ribose) at glycosidic (1''-2') linkage of ribose- ribose bond to produce free ADP-D-ribose. -!- Specific to (1''-2') linkage of ribose-ribose bond of poly(ADP-D- ribose).
3.5.1.-	In linear amides. based on mapping to UniProt Q9NX46

UniProtKB Entries (1)

ARHL2_HUMAN

Homo sapiens

ADP-ribose glycohydrolase ARH3

PDB Structure

PDB	5ZQY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-function analyses reveal the mechanism of the ARH3-dependent hydrolysis of ADP-ribosylation. Wang, M., Yuan, Z., Xie, R., Ma, Y., Liu, X., Yu, X. J. Biol. Chem.