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1 keywords

CATH Domain 5yl2F03

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1490 Dna Ligase; domain 1
Homologous Superfamily 3.30.1490.20 ATP-grasp fold, A domain

Domain Context

CATH Clusters

Superfamily ATP-grasp fold, A domain
Functional Family

Enzyme Information

UniProtKB Entries (3)

P02554
TBB_PIG
Sus scrofa
Tubulin beta chain
E1BQ43
E1BQ43_CHICK
Gallus gallus
Uncharacterized protein
P63043
STMN4_RAT
Rattus norvegicus
Stathmin-4

PDB Structure

PDB 5YL2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
Jianhong, Y., Wei, Y., Yamei, Y., Yuxi, W., Tao, Y., Linlin, X., Xue, Y., Caofeng, L., Zuowei, L., Xiaoxin, C., Mengshi, H., Li, Z., Qiang, Q., Heying, P., Dan, L., Fang, W., Peng, B., Jiaolin, W., Haoyu, Y., Lijuan, C.
J. Biol. Chem.
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