CATH Domain 5xnxD02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.460	Beta Polymerase; domain 2
	3.30.460.10	Beta Polymerase, domain 2

Domain Context

CATH Clusters

Superfamily	Beta Polymerase, domain 2
Functional Family	GTP pyrophosphokinase RelA

Enzyme Information

2.7.6.5	GTP diphosphokinase. based on mapping to UniProt P9WHG9 ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate. -!- GDP can also act as acceptor.
3.1.7.2	Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase. based on mapping to UniProt P9WHG9 Guanosine 3',5'-bis(diphosphate) + H(2)O = guanosine 5'-diphosphate + diphosphate.

UniProtKB Entries (1)

RELA_MYCTU

Mycobacterium tuberculosis H37Rv

Bifunctional (p)ppGpp synthase/hydrolase RelA

PDB Structure

PDB	5XNX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystallographic and solution structure of the N-terminal domain of the Rel protein from Mycobacterium tuberculosis Singal, B., Balakrishna, A.M., Nartey, W., Manimekalai, M.S.S., Jeyakanthan, J., Gruber, G. FEBS Lett.