CATH Domain 5vsbB02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.20	Single Sheet
	2.20.210	ubp-family deubiquitinating enzyme fold
	2.20.210.10	ubp-family deubiquitinating enzyme superfamily

Domain Context

CATH Clusters

Superfamily	ubp-family deubiquitinating enzyme superfamily
Functional Family

Enzyme Information

3.4.19.12

Ubiquitinyl hydrolase 1.

based on mapping to UniProt Q93009

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Q93009

UBP7_HUMAN

Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 7

PDB Structure

PDB	5VSB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7. Lamberto, I., Liu, X., Seo, H.S., Schauer, N.J., Iacob, R.E., Hu, W., Das, D., Mikhailova, T., Weisberg, E.L., Engen, J.R., Anderson, K.C., Chauhan, D., Dhe-Paganon, S., Buhrlage, S.J. Cell Chem Biol

Network disruptions