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1 keywords

CATH Domain 5v4wA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.367 Hexokinase; domain 1
Homologous Superfamily 3.40.367.20  

Domain Context

CATH Clusters

Superfamily 3.40.367.20
Functional Family Hexokinase 1

Enzyme Information

2.7.1.2
Glucokinase.
based on mapping to UniProt P35557
ATP + D-glucose = ADP + D-glucose 6-phosphate.
-!- A group of enzymes found in invertebrates and microorganisms highly specific for glucose.

UniProtKB Entries (1)

P35557
HXK4_HUMAN
Homo sapiens
Glucokinase

PDB Structure

PDB 5V4W
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators.
Cheruvallath, Z.S., Gwaltney, S.L., Sabat, M., Tang, M., Wang, H., Jennings, A., Hosfield, D., Lee, B., Wu, Y., Halkowycz, P., Grimshaw, C.E.
Bioorg. Med. Chem. Lett.
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