×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

1 keywords

CATH Domain 5u2nA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.20 Alpha-Beta Barrel
Topology 3.20.20 TIM Barrel
Homologous Superfamily 3.20.20.70 Aldolase class I

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

2.4.2.12
Nicotinamide phosphoribosyltransferase.
based on mapping to UniProt P43490
Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho- alpha-D-ribose 1-diphosphate.

UniProtKB Entries (1)

P43490
NAMPT_HUMAN
Homo sapiens
Nicotinamide phosphoribosyltransferase

PDB Structure

PDB 5U2N
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.
Wilsbacher, J.L., Cheng, M., Cheng, D., Trammell, S.A.J., Shi, Y., Guo, J., Koeniger, S.L., Kovar, P.J., He, Y., Selvaraju, S., Heyman, H.R., Sorensen, B.K., Clark, R.F., Hansen, T.M., Longenecker, K.L., Raich, D., Korepanova, A.V., Cepa, S., Towne, D.L., Abraham, V.C., Tang, H., Richardson, P.L., McLoughlin, S.M., Badagnani, I., Curtin, M.L., Michaelides, M.R., Maag, D., Buchanan, F.G., Chiang, G.G., Gao, W., Rosenberg, S.H., Brenner, C., Tse, C.
Mol. Cancer Ther.
CATH-Gene3D is a Global Biodata Core Resource Learn more...