CATH Domain 5tegB00

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.270	Beta-clip-like
	2.170.270.10	SET domain

Domain Context

CATH Clusters

Superfamily	SET domain
Functional Family	Histone-lysine N-methyltransferase

Enzyme Information

2.1.1.43	Histone-lysine N-methyltransferase. based on mapping to UniProt Q9NQR1 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
2.1.1.-	Methyltransferases. based on mapping to UniProt Q9NQR1

UniProtKB Entries (1)

H4_HUMAN

Homo sapiens

Histone H4

PDB Structure

PDB	5TEG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8. Judge, R.A., Zhu, H., Upadhyay, A.K., Bodelle, P.M., Hutchins, C.W., Torrent, M., Marin, V.L., Yu, W., Vedadi, M., Li, F., Brown, P.J., Pappano, W.N., Sun, C., Petros, A.M. ACS Med Chem Lett