CATH Domain 5pntA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.2300	Response regulator

Domain Context

CATH Clusters

Superfamily	3.40.50.2300
Functional Family	Low molecular weight phosphotyrosine protein

Enzyme Information

3.1.3.48	Protein-tyrosine-phosphatase. based on mapping to UniProt P24666 Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. -!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
3.1.3.2	Acid phosphatase. based on mapping to UniProt P24666 A phosphate monoester + H(2)O = an alcohol + phosphate. -!- Wide specificity. -!- Also catalyzes transphosphorylations.

UniProtKB Entries (1)

PPAC_HUMAN

Homo sapiens

Low molecular weight phosphotyrosine protein phosphatase

PDB Structure

PDB	5PNT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity. Zhang, M., Stauffacher, C.V., Lin, D., Van Etten, R.L. J.Biol.Chem.