×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

1 keywords

CATH Domain 5kvvB02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.110 L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
Homologous Superfamily 3.90.110.10 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family Malate dehydrogenase

Enzyme Information

1.1.1.37
Malate dehydrogenase.
based on mapping to UniProt P9WK13
(S)-malate + NAD(+) = oxaloacetate + NADH.
-!- Also oxidizes some other 2-hydroxydicarboxylic acids.

UniProtKB Entries (1)

P9WK13
MDH_MYCTU
Mycobacterium tuberculosis H37Rv
Malate dehydrogenase

PDB Structure

PDB 5KVV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of Malate Dehydrogenase in complex with NADH from Mycobacterium tuberculosis
Cheng, Y.S., Sacchettini, J.C.
To Be Published
CATH-Gene3D is a Global Biodata Core Resource Learn more...