CATH Domain 5kizA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.450	Beta-Lactamase
	3.30.450.20	PAS domain

Domain Context

CATH Clusters

Superfamily	PAS domain
Functional Family	Hypoxia-inducible factor 1-alpha isoform 1

Enzyme Information

UniProtKB Entries (1)

EPAS1_HUMAN

Homo sapiens

Endothelial PAS domain-containing protein 1

PDB Structure

PDB	5KIZ
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Repacking of internal hydrated HIF-2 alpha cavity removes allosteric binding site Correa, F., Key, J., Kuhlman, B., Gardner, K.H. To Be Published