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1 keywords

CATH Domain 5hw4C02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.950 Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2
Homologous Superfamily 3.30.950.10 Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2

Domain Context

CATH Clusters

Superfamily Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2
Functional Family Ribosomal RNA small subunit methyltransferase I

Enzyme Information

2.1.1.198
16S rRNA (cytidine(1402)-2'-O)-methyltransferase.
based on mapping to UniProt P67087
S-adenosyl-L-methionine + cytidine(1402) in 16S rRNA = S-adenosyl-L- homocysteine + 2'-O-methylcytidine(1402) in 16S rRNA.
-!- RsmI catalyzes the 2'-O-methylation of cytidine(1402) and RsmH (EC 2.1.1.199) catalyzes the N(4)-methylation of cytidine(1402) in 16S rRNA. -!- Both methylations are necessary for efficient translation initiation at the UUG and GUG codons.

UniProtKB Entries (1)

P67087
RSMI_ECOLI
Escherichia coli K-12
Ribosomal RNA small subunit methyltransferase I

PDB Structure

PDB 5HW4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Insights into the Methylation of C1402 in 16S rRNA by Methyltransferase RsmI
Zhao, M., Zhang, H., Liu, G., Wang, L., Wang, J., Gao, Z., Dong, Y., Zhang, L., Gong, Y.
Plos One
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