CATH Domain 5hi4H01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.10	Immunoglobulins

Domain Context

CATH Clusters

Superfamily	Immunoglobulins
Functional Family	Immunoglobulin heavy variable 3-23

Enzyme Information

UniProtKB Entries (1)

IL17_HUMAN

Homo sapiens

Interleukin-17A

PDB Structure

PDB	5HI4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists. Liu, S., Dakin, L.A., Xing, L., Withka, J.M., Sahasrabudhe, P.V., Li, W., Banker, M.E., Balbo, P., Shanker, S., Chrunyk, B.A., Guo, Z., Chen, J.M., Young, J.A., Bai, G., Starr, J.T., Wright, S.W., Bussenius, J., Tan, S., Gopalsamy, A., Lefker, B.A., Vincent, F., Jones, L.H., Xu, H., Hoth, L.R., Geoghegan, K.F., Qiu, X., Bunnage, M.E., Thorarensen, A. Sci Rep