CATH Domain 5h4jA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.70	Distorted Sandwich
	2.70.40	Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A
	2.70.40.10	Deoxyuridine triphosphatase (dUTPase)

Domain Context

CATH Clusters

Superfamily	2.70.40.10
Functional Family	Deoxyuridine triphosphatase

Enzyme Information

3.6.1.23

dUTP diphosphatase.

based on mapping to UniProt P33316

dUTP + H(2)O = dUMP + diphosphate.

UniProtKB Entries (1)

DUT_HUMAN

Homo sapiens

Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

PDB Structure

PDB	5H4J
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy. Yano, W., Yokogawa, T., Wakasa, T., Yamamura, K., Fujioka, A., Yoshisue, K., Matsushima, E., Miyahara, S., Miyakoshi, H., Taguchi, J., Chong, K.T., Takao, Y., Fukuoka, M., Matsuo, K. Mol. Cancer Ther.