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CATH Classification

Domain Context

CATH Clusters

Superfamily Ribosomal protein S3, C-terminal domain
Functional Family 40S ribosomal protein S3

Enzyme Information

4.2.99.18
DNA-(apurinic or apyrimidinic site) lyase.
based on mapping to UniProt P23396
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.

UniProtKB Entries (1)

P62847
RS24_HUMAN
Homo sapiens
40S ribosomal protein S24

PDB Structure

PDB 5FLX
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Molecular Architecture of the Ribosome-Bound Hepatitis C Virus Internal Ribosomal Entry Site RNA.
Yamamoto, H., Collier, M., Loerke, J., Ismer, J., Schmidt, A., Hilal, T., Sprink, T., Yamamoto, K., Mielke, T., Burger, J., Shaikh, T.R., Dabrowski, M., Hildebrand, P.W., Scheerer, P., Spahn, C.M.
Embo J.
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