CATH Domain 5c2yB00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.40	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
	1.25.40.820	Rtr1/RPAP2 domain

Domain Context

CATH Clusters

Superfamily	1.25.40.820
Functional Family	RTR1p CTD phosphatase

Enzyme Information

3.1.3.16

Protein-serine/threonine phosphatase.

based on mapping to UniProt P40084

[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.

-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (1)

P40084

RTR1_YEAST

Saccharomyces cerevisiae S288C

RNA polymerase II subunit B1 CTD phosphatase RTR1

PDB Structure

PDB	5C2Y
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase. Irani, S., Yogesha, S.D., Mayfield, J., Zhang, M., Zhang, Y., Matthews, W.L., Nie, G., Prescott, N.A., Zhang, Y.J. Sci.Signal.