CATH Domain 5bwxB02

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.10	D-amino Acid Aminotransferase; Chain A, domain 2
	3.20.10.10	D-amino Acid Aminotransferase, subunit A, domain 2

Superfamily	D-amino Acid Aminotransferase, subunit A, domain 2
Functional Family	Branched-chain-amino-acid aminotransferase, mitochondrial

2.6.1.42

Branched-chain-amino-acid transaminase.

based on mapping to UniProt O15382

L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.

-!- Also acts on L-isoleucine and L-valine. -!- Different from EC 2.6.1.66.

BCAT2_HUMAN

Homo sapiens

Branched-chain-amino-acid aminotransferase, mitochondrial

PDB	5BWX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits. Bertrand, S.M., Ancellin, N., Beaufils, B., Bingham, R.P., Borthwick, J.A., Boullay, A.B., Boursier, E., Carter, P.S., Chung, C.W., Churcher, I., Dodic, N., Fouchet, M.H., Fournier, C., Francis, P.L., Gummer, L.A., Herry, K., Hobbs, A., Hobbs, C.I., Homes, P., Jamieson, C., Nicodeme, E., Pickett, S.D., Reid, I.H., Simpson, G.L., Sloan, L.A., Smith, S.E., Somers, D.O., Spitzfaden, C., Suckling, C.J., Valko, K., Washio, Y., Young, R.J. J.Med.Chem.