CATH Domain 5a37B01

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.418	Actin-binding Protein, T-fimbrin; domain 1
	1.10.418.10	Calponin-like domain

Domain Context

CATH Clusters

Superfamily	Calponin-like domain
Functional Family	Alpha-actinin, sarcomeric

Enzyme Information

UniProtKB Entries (1)

ACTN2_HUMAN

Homo sapiens

Alpha-actinin-2

PDB Structure

PDB	5A37
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Hypertrophic Cardiomyopathy Mutations in the Calponin-Homology Domain of Actn2 Affect Actin Binding and Cardiomyocyte Z-Disc Incorporation. Haywood, N., Wolny, M., Rogers, B., Trinh, C.H., Shuping, Y., Edwards, T.A., Peckham, M. Biochem.J.