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1 keywords

CATH Domain 4zqrC00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.20 Alpha-Beta Barrel
Topology 3.20.20 TIM Barrel
Homologous Superfamily 3.20.20.70 Aldolase class I

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

1.1.1.205
IMP dehydrogenase.
based on mapping to UniProt P9WKI7
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH.
-!- The enzyme acts on the hydroxy group of the hydrated derivative of the substrate. -!- Formerly EC 1.2.1.14.

UniProtKB Entries (1)

P9WKI7
IMDH_MYCTU
Mycobacterium tuberculosis H37Rv
Inosine-5'-monophosphate dehydrogenase

PDB Structure

PDB 4ZQR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds.
Makowska-Grzyska, M., Kim, Y., Gorla, S.K., Wei, Y., Mandapati, K., Zhang, M., Maltseva, N., Modi, G., Boshoff, H.I., Gu, M., Aldrich, C., Cuny, G.D., Hedstrom, L., Joachimiak, A.
Plos One
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