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1 keywords

CATH Domain 4xr8H02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.240 CRO Repressor
Homologous Superfamily 3.30.240.40 E6 early regulatory protein

Domain Context

CATH Clusters

Superfamily E6 early regulatory protein
Functional Family Protein E6

Enzyme Information

UniProtKB Entries (3)

P03126
VE6_HPV16
Human papillomavirus type 16
Protein E6
Q05086
UBE3A_HUMAN
Homo sapiens
Ubiquitin-protein ligase E3A
P0AEX9
MALE_ECOLI
Escherichia coli K-12
Maltose/maltodextrin-binding periplasmic protein

PDB Structure

PDB 4XR8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
Martinez-Zapien, D., Ruiz, F.X., Poirson, J., Mitschler, A., Ramirez, J., Forster, A., Cousido-Siah, A., Masson, M., Pol, S.V., Podjarny, A., Trave, G., Zanier, K.
Nature
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