CATH Domain 4utzA02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1600	SIR2/SIRT2 'Small Domain'
	3.30.1600.10	SIR2/SIRT2 'Small Domain'

Domain Context

CATH Clusters

Superfamily	SIR2/SIRT2 'Small Domain'
Functional Family	NAD-dependent protein deacylase sirtuin-5, mitochondrial

Enzyme Information

3.5.1.-

In linear amides.

based on mapping to UniProt Q6DHI5

UniProtKB Entries (2)

Q6DHI5	SIR5_DANRE Danio rerio NAD-dependent protein deacylase sirtuin-5, mitochondrial
P31327	CPSM_HUMAN Homo sapiens Carbamoyl-phosphate synthase [ammonia], mitochondrial

PDB Structure

PDB	4UTZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors. Roessler, C., Nowak, T., Pannek, M., Gertz, M., Nguyen, G.T., Scharfe, M., Born, I., Sippl, W., Steegborn, C., Schutkowski, M. Angew.Chem.Int.Ed.Engl.